82299-13-6

Upstream product

• 536-74-3 phenylacetylene 
• 20147-41-5 (Z)-N-phenyl-1-(pyridin-3-yl)methanimine oxide 
• 73570-11-3 N-(pyridin-3-ylmethyl)aniline 
• 500-22-1 3-pyridinecarboxaldehyde 
• 62-53-3 aniline 
• 622-37-7 Phenyl azide 

Downstream Products

• 6294-65-1 2-pyridin-3-yl-quinoline 
• 159110-62-0 Phenyl-(1-pyridin-3-yl-but-3-enyl)-amine 
• 73570-11-3 N-(pyridin-3-ylmethyl)aniline 

Relevant academic research and scientific papers

Inverse Hydroboration of Imines with NHC-Boranes Is Promoted by Diphenyl Disulfide and Visible Light

We describe a simple and efficient procedure for nucleophilic borylation of imines in the absence of a photoredox catalyst. Visible light irradiation of an acetonitrile solution of an imine, an NHC-borane, and diphenyl disulfide (10 mol %) provides various stable α-amino NHC-boranes in good yields. The reaction proceeds via addition of a nucleophilic boryl radical to an imine, followed by hydrogen abstraction from thiophenol, which is generated from NHC-borane and diphenyl disulfide.

Synthesis, antimicrobial screening, homology modeling, and molecular docking studies of a new series of Schiff base derivatives as prospective fungal inhibitor candidates

Twelve new Schiff base derivatives have been prepared by the condensation reaction of different amino substituted compounds (aniline, pyridin-2-amine, o-toluidine, 2-nitrobenzenamine, 4-aminophenol, and 3-aminopropanol) and substituted aldehydes such as n

Superelectrophilic Diels–Alder reactions and oxidations leading to heterocyclic biaryl compounds

Heterocyclic imines provide biaryl products by a two-step transformation. The first transformation involves a Diels–Alder reaction with a multiply protonated imine to give a tetrahydroquinoline product, whereas the second step involves oxidation with elem

Synergistic Photoredox Catalysis and Organocatalysis for Inverse Hydroboration of Imines

The first catalytic inverse hydroboration of imines with N-heterocyclic carbene (NHC) boranes has been realized by means of cooperative organocatalysis and photocatalysis. This catalytic combination provides a promising platform for promoting NHC-boryl radical chemistry under sustainable and radical-initiator-free conditions. The highly important functional-group compatibility and possible application in late-stage hydroborations represent an important step forward to an enhanced α-amino organoboron library.

Antifungal and cytotoxic activities of some N-substituted aniline derivatives bearing a hetaryl fragment

Diverse N-substituted anilines bearing hetaryl fragments were easily prepared from corresponding aldimines derived from commercially available aromatic aldehydes and anilines. 2-Furyl substituted anilines showed very good antifungal activities against dermatophytes, particularly against Trichophyton rubrum (MIC = 3.12-6.25 μg/mL). In addition, all active compounds, 45-47, 73, and 74, were tested for cytotoxic activities against breast (MCF-7), lung (H-460), and central nervous system (SF-268) human cancer cell lines with the NCI-anticancer-drug screen. The activity of amines described in this paper, along with the low toxicity of most of them, shows promise for the future development of non-toxic new antimycotic agents.

Synthesis and rearrangement of 1,2,3-triheteroaryl(aryl)-substituted aziridines

Aziridines carrying three (or two) heteroaryl groups with electron-withdrawing effects were synthesised with sufficient diastereoselectivity. The cis aziridines are susceptible to ring opening and rearrangement when the formation of secondary enamines in

Anion binding in (arene)ruthenium(II)-based hosts

Asymmetric ruthenium(II) complexes of a flexible aminomethylpyridine derivative exhibit diastereotopic ligand methylene protons, as measured by NMR spectroscopy; binding of external anions renders these protons equivalent possibly by increasing dynamicall

In vitro antifungal activity of new series of homoallylamines and related compounds with inhibitory properties of the synthesis of fungal cell wall polymers

The synthesis, in vitro antifungal evaluation and SAR studies of 101 compounds of the 4-aryl-, 4-alkyl-, 4-pyridyl or -quinolinyl-4-N-arylamino-1-butenes series and related compounds, are reported here. Active structures showed to inhibit (1,3)-β-D-glucan and mainly chitin synthases, enzymes that catalyze the synthesis of the major fungal cell wall polymers.

Molecular structure of di-aryl-aldimines by multinuclear magnetic resonance and X-ray diffraction

The complete 1H, 13C and 15N NMR analyses for a series of 25 diaryl-aldimines containing phenyl, pyridyl, pyrazolone and furanyl moieties are described herein. Detailed evaluation of substituent chemical shift and coupling constant effects showed that interaction between the lone pair of the pyrazolone carbonyl group or the nitrogen of 2-substitued pyridines with the aldimine hydrogen increases the 1JCH value and shifts the resonance signal for this hydrogen to high frequency, in the 1H NMR spectra. The X-ray crystal structure analysis of pyrazolone substituted aldimines evidenced the planarity of the aryl groups which are conjugated with the C=N double bond. In the case of the N-(2-pyridinemethylene)-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one, two rotamers were observed in the same unit cell.

Oxidation of various secondary amines to imines with N-tert-butylphenylsulfinimidoyl chloride

Various secondary amines were smoothly oxidized to the corresponding imines at -78 °C by using N-tert-butylphenylsulfinimidoyl chloride and DBU.