159116-97-9

Basic information

• Product Name: Phosphonic acid, [(R)-aminophenylmethyl]-, diethyl ester
• CAS NO: 159116-97-9
• Molecular Formula: C11H18NO3P
• Molecular Weight: 243.243
• Mol File: 159116-97-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, [(R)-aminophenylmethyl]-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, [(R)-aminophenylmethyl]-, diethyl ester(159116-97-9)
• EPA Substance Registry System: Phosphonic acid, [(R)-aminophenylmethyl]-, diethyl ester(159116-97-9)

Safety Data

• Hazardous Substances Data: 159116-97-9(Hazardous Substances Data)

Upstream product

• 72974-01-7 diethyl [phenyl(phenylhydrazono)methyl]phosphonate 
• 3277-27-8 diethyl benzoylphosphonate 
• 350479-90-2 (S,E)-N-benzylidene-4-methylbenzenesulfinamide 
• 201610-50-6 (S_S,R)-(+)-O,O-diethyl N-(p-toluenesulfinyl)-1-amino-1-phenyl-methylphosphonate 
• 1255703-17-3 C₂₃H₄₁N₃O₄P₂ 
• 144302-38-5 (R)-benzylidene-(2-methoxy-1-phenylethyl)amine 

Downstream Products

• 37714-05-9 (R)-1-amino-1-phenylmethylphosphonic acid 

Relevant articles and documents

One-Pot Two-Step Synthesis of Optically Active α-Amino Phosphonates by Palladium-Catalyzed Hydrogenation/Hydrogenolysis of α-Hydrazono Phosphonates

An efficient and convenient one-pot procedure for the stereoselective catalytic synthesis of ring-substituted [amino(phenyl)methyl]phosphonates has been developed. The enantioselective hydrogenation of easily available diisopropyl (Z)-[aryl(phenylhydrazono)methyl]phosphonates using palladium(II) acetate as a precatalyst, (R)-2,2′-bis(diphenylphosphino)-5,5′-dichloro-6,6′-dimethoxy-1,1′-biphenyl [(R)-Cl–MeO-BIPHEP] as a ligand, and (1S)-(+)-10-camphorsulfonic acid as an activator in a mixture of 2,2,2-trifluoroethanol and methylene chloride at ambient temperature results in the formation of corresponding [aryl(2-phenylhydrazino)methyl]phosphonates. The subsequent cleavage of the N?N bond has been accomplished with molecular hydrogen after the addition of palladium on carbon and methanol into crude reaction mixture to afford the optically active [amino(aryl)methyl]phosphonates. The method is operationally simple and provides an appreciable enantioselectivity up to 98 % ee. (Figure presented.).

Chiral Br?nsted acid-catalyzed hydrophosphonylation of imines-DFT study on the effect of substituents of phosphoric acid

The enantioselective hydrophosphonylation reaction of diisopropyl phosphite with aldimine furnished α-amino phosphonates with high enantioselectivities by means of a chiral phosphoric acid. DFT calculation of the effect of 3,3′-substituents of the phospho

Studies toward the Asymmetric Synthesis of α-Amino Phosphonic Acids via the Addition of Phosphites to Enantiopure Sulfinimines

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