159148-87-5Relevant academic research and scientific papers
General base-guanidinium cooperation in bifunctional artificial phosphodiesterases
Salvio, Riccardo,Cacciapaglia, Roberta,Mandolini, Luigi
, p. 5438 - 5443 (2011)
Artificial phosphodiesterases that combine a guanidinium unit with a general base connected by a m-xylylene linker catalyze the transesterification of the RNA model compound 2-hydroxypropyl p-nitrophenyl phosphate (HPNP). The bifunctional catalysts presented in this work show varying extents of cooperation between catalytic units and a rate enhancement of 4 ×10 4 in the most favorable case.
