15917-59-6

Upstream product

• 93790-54-6 [2-(4-iodophenoxy)ethyl]dimethylamine 
• 197250-99-0 1-(but-1-yn-1-yl)-4-methoxybenzene 
• 696-62-8 para-iodoanisole 
• 624731-40-4 Z-(Et)(C₆H₅)CC(4-Me₂NCH₂CH₂OC₆H₄)(B(pin)) 
• 624731-33-5 E-(Et)(C₆H₅)CC(4-Me₂N(CH₂)2OC₆H₄)(SiMe₂C₅H₄N) 

Relevant academic research and scientific papers

Catalytic carbometalation/cross-coupling sequence across alkynyl(2-pyridyl)silanes leading to a diversity-oriented synthesis of tamoxifen-type tetrasubstituted olefins

A general synthetic scheme for tamoxifen-type tetrasubstituted olefins based on the novel Cu-catalyzed carbomagnesation across alkynyl(2-pyridyl)silane has been developed. A wide array of electronically and structurally diverse tetrasubstituted olefins can be prepared in a regiocontrolled, stereo-controlled, and diversity-oriented manner. Noteworthy features are that (i) the three aryl groups, which are believed to be important (essential) for anti-estrogenic activity, can be varied at will because they all stem from readily available aryl iodides, and (ii) any stereo- and regioisomers can, in principle, be prepared by simply changing the order use of the aryl iodides in the sequence.