624731-40-4

Basic information

• Product Name: Z-(Et)(C₆H₅)CC(4-Me₂NCH₂CH₂OC₆H₄)(B(pin))
• Synonyms: Z-(Et)(C₆H₅)CC(4-Me₂NCH₂CH₂OC₆H₄)(B(pin))
• CAS NO: 624731-40-4
• Molecular Weight: 421.388
• Mol File: 624731-40-4.mol

Chemical Properties

• CAS DataBase Reference: Z-(Et)(C₆H₅)CC(4-Me₂NCH₂CH₂OC₆H₄)(B(pin))(CAS DataBase Reference)
• NIST Chemistry Reference: Z-(Et)(C₆H₅)CC(4-Me₂NCH₂CH₂OC₆H₄)(B(pin))(624731-40-4)
• EPA Substance Registry System: Z-(Et)(C₆H₅)CC(4-Me₂NCH₂CH₂OC₆H₄)(B(pin))(624731-40-4)

Safety Data

• Hazardous Substances Data: 624731-40-4(Hazardous Substances Data)

Upstream product

• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 10294-34-5 boron trichloride 
• 624731-33-5 E-(Et)(C₆H₅)CC(4-Me₂N(CH₂)2OC₆H₄)(SiMe₂C₅H₄N) 
• 93790-54-6 [2-(4-iodophenoxy)ethyl]dimethylamine 

Downstream Products

• 10540-29-1 tamoxifen 
• 13002-65-8 (E)-tamoxifen 
• 15917-59-6 (2-{4-[(Z)-1-(4-Methoxy-phenyl)-2-phenyl-but-1-enyl]-phenoxy}-ethyl)-dimethyl-amine 
• 15917-60-9 (2-{4-[(E)-1-(4-Methoxy-phenyl)-2-phenyl-but-1-enyl]-phenoxy}-ethyl)-dimethyl-amine 

Relevant articles and documents

Catalytic carbometalation/cross-coupling sequence across alkynyl(2-pyridyl)silanes leading to a diversity-oriented synthesis of tamoxifen-type tetrasubstituted olefins

A general synthetic scheme for tamoxifen-type tetrasubstituted olefins based on the novel Cu-catalyzed carbomagnesation across alkynyl(2-pyridyl)silane has been developed. A wide array of electronically and structurally diverse tetrasubstituted olefins can be prepared in a regiocontrolled, stereo-controlled, and diversity-oriented manner. Noteworthy features are that (i) the three aryl groups, which are believed to be important (essential) for anti-estrogenic activity, can be varied at will because they all stem from readily available aryl iodides, and (ii) any stereo- and regioisomers can, in principle, be prepared by simply changing the order use of the aryl iodides in the sequence.

Diversity-Oriented Synthesis of Tamoxifen-type Tetrasubstituted Olefins

A general synthetic scheme for tamoxifen-type tetrasubstituted olefins based on the novel Cu-catalyzed carbomagnesation across alkynyl(2-pyridyl)silane has been developed. A wide array of electronically and structurally diverse tetrasubstituted olefins can be prepared in a regiocontrolled, stereocontrolled, and diversity-oriented manner. Noteworthy features are that (i) the three aryl groups, which are believed to be important (essential) for anti-estrogenic activity, can be varied at will because they all stem from readily available aryl iodides, and (ii) any stereo- and regioisomers can, in principle, be prepared by simply changing the applying order of aryl iodides into the sequence. Copyright