1591916-54-9Relevant academic research and scientific papers
Synthesis of 2-BMIDA 6,5-bicyclic heterocycles by Cu(i)/Pd(0)/Cu(II) cascade catalysis of 2-iodoaniline/phenols
Seath, Ciaran P.,Wilson, Kirsty L.,Campbell, Angus,Mowat, Jenna M.,Watson, Allan J.B.
, p. 8703 - 8706 (2016)
A one-pot cascade reaction for the synthesis of 2-BMIDA 6,5-bicyclic heterocycles has been developed using Cu(i)/Pd(0)/Cu(ii) catalysis. 2-Iodoanilines and phenols undergo a Cu(i)/Pd(0)-catalyzed Sonogashira reaction with ethynyl BMIDA followed by in situ Cu(ii)-catalyzed 5-endo-dig cyclization to generate heterocyclic scaffolds with a BMIDA functional group in the 2-position. The method provides efficient access to borylated indoles, benzofurans, and aza-derivatives, which can be difficult to access through alternative methods.
An approach to cyclohepta[ b ]indoles through an allenamide (4 + 3) cycloaddition-grignard cyclization-chugaev elimination sequence
He, Shuzhong,Hsung, Richard P.,Presser, William R.,Ma, Zhi-Xiong,Haugen, Bryan J.
supporting information, p. 2180 - 2183 (2014/05/06)
A strategy for synthesizing highly functionalized cyclohepta[b]indoles through a concise (4 + 3) cycloaddition-cyclization-elimination sequence is described. The cycloaddition features nitrogen-stabilized oxyallyl cations derived from epoxidations of N-ar
