15922-50-6

Basic information

• Product Name: N-cyclooctylidene(phenyl)methanamine
• Synonyms: N-cyclooctylidene(phenyl)methanamine
• CAS NO: 15922-50-6
• Molecular Weight: 215.338
• Mol File: 15922-50-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: N-cyclooctylidene(phenyl)methanamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-cyclooctylidene(phenyl)methanamine(15922-50-6)
• EPA Substance Registry System: N-cyclooctylidene(phenyl)methanamine(15922-50-6)

Safety Data

• Hazardous Substances Data: 15922-50-6(Hazardous Substances Data)

Upstream product

• 502-49-8 cycloactanone 
• 100-46-9 benzylamine 

Downstream Products

• 256642-06-5 N-benzyl-2-bromo-N-(cyclooct-1-enyl)-2-methylpropionamide 
• 1375414-49-5 1-benzyl-1,2-diazaspiro[2.7]decane 
• 13310-61-7 N-Benzyl-N-cyclooctyl-<2>naphthoylamid 
• 13310-06-0 Benzyl-cyclooctyl-<2>naphthylmethyl-amin 
• 13310-12-8 N-Cyclooctyl-N-benzyl-glycin-aethylester 
• 13310-60-6 N-Benzyl-N-cyclooctyl-pivaloylamid 
• 13310-59-3 N-Benzyl-N-cyclooctyl-isobutyrylamid 
• 13310-04-8 Cyclooctyl-benzyl-neopentyl-amin 
• 13310-02-6 Benzyl-cyclooctyl-isobutyl-amin 
• 13310-14-0 Benzyl-cyclooctyl-methallyl-amin 
• 13310-13-9 Allyl-benzyl-cyclooctyl-amin 
• 109240-97-3 C₂₂H₂₃NO 
• 270900-84-0 3-benzyl-6-methyl-3,4,5,6-tetrahydrospiro[1,2,3-oxatiazine-2,2-dioxide-4,1'cyclooctane] 
• 216369-62-9 1-benzylspiro[pyrrolidine-2,1'-cyclooctane] 

Relevant articles and documents

Solvent dependency of the yield of an N-monosubstituted diaziridine: A GC-MS study

Due to the growing importance of diaziridines in the drug design and the increasing popularity of diazirines as carbene precursors, the solvent influence on the yield of an N-monosubstituted diaziridine has been studied. It was observed that data points w

An improved and stereoselective route to all-cis-2,6-disubstituted 4-hydroxypiperidines from accessible 4-substituted 4-N-benzylaminobut-1-enes

The reaction between allylmagnesium bromide and imines 5a-l leads to the corresponding 4-substituted 4-N-benzylaminobut-1-enes 6a-1, which were oxidized in a regioselective manner to the alkenylnitrones 7a-l. The intramolecular 1,3-dipolar cycloaddition of these nitrones gave 2-spiroannulated or 2-substituted 6-exo-phenyl-1-aza-7-oxabicyclo[2.2.1]heptanes 8a-j. Reductive cleavage of the N-O bond of the obtained bicycles afforded the diverse substituted 4-hydroxypiperidines 9a-h in good yields. This stereoselective approach allowed the preparation of all-cis-4-hydroxy-6-phenyl-2-nonylpiperidine (9i), a close analogue of dendrobatid frog alkaloid 241D.

Synthesis of new spiro-N-heterocycles with cyclooctane fragment from N- (1-alkenylcyclooctyl)-N-aryl(benzyl) amines

The homoallylic amines (6-10) derived from N-cyclooctylidenearyl (benzyl)amines and allyl- or prenylmagnesium bromides as organometallic reagents have been used for synthesis of spiro-N-heterocycles. The tetrahydrospiro[3H-2-benzazepine-3,1'-cyclooctanes] (11 and 12) have been obtained from the homoallylamines (6 and 7) under acidic conditions. The tetrahydro-1-benzazepine (15) spiroannulated with a cyclooctane moiety has been prepared by treating the homoallylic amine (9) with conc. sulfuric acid. Treatment of the homoallylmine (6) with 92% sulfuric acid in chloroform at reflux afforded tetrahydrospiro[1,2,3-oxathiazine-2,2-dioxide-4,1'- cyclooctane] (17). The latter has been converted into 1-benzyl-4- methylspiro[azetidine-2,1'-cyclooctane] (18). The homoallylamine (6) has been cyclized into the 1-benzylspiro[pyrrolidine-2,1'-cyclooctane] (19).