216369-62-9

Basic information

• Product Name: 1-benzylspiro[pyrrolidine-2,1'-cyclooctane]
• Synonyms: 1-benzylspiro[pyrrolidine-2,1'-cyclooctane]
• CAS NO: 216369-62-9
• Molecular Weight: 257.419
• Mol File: 216369-62-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-benzylspiro[pyrrolidine-2,1'-cyclooctane](CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzylspiro[pyrrolidine-2,1'-cyclooctane](216369-62-9)
• EPA Substance Registry System: 1-benzylspiro[pyrrolidine-2,1'-cyclooctane](216369-62-9)

Safety Data

• Hazardous Substances Data: 216369-62-9(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 15922-50-6 N-cyclooctylidene(phenyl)methanamine 
• 502-49-8 cycloactanone 
• 199734-95-7 N-(1-allylcyclooctyl)benzylamine 

Downstream Products

• 127687-61-0 spiro[pyrrolidine-2,1'-cyclooctane] 

Relevant articles and documents

Synthesis of new spiro-N-heterocycles with cyclooctane fragment from N- (1-alkenylcyclooctyl)-N-aryl(benzyl) amines

The homoallylic amines (6-10) derived from N-cyclooctylidenearyl (benzyl)amines and allyl- or prenylmagnesium bromides as organometallic reagents have been used for synthesis of spiro-N-heterocycles. The tetrahydrospiro[3H-2-benzazepine-3,1'-cyclooctanes] (11 and 12) have been obtained from the homoallylamines (6 and 7) under acidic conditions. The tetrahydro-1-benzazepine (15) spiroannulated with a cyclooctane moiety has been prepared by treating the homoallylic amine (9) with conc. sulfuric acid. Treatment of the homoallylmine (6) with 92% sulfuric acid in chloroform at reflux afforded tetrahydrospiro[1,2,3-oxathiazine-2,2-dioxide-4,1'- cyclooctane] (17). The latter has been converted into 1-benzyl-4- methylspiro[azetidine-2,1'-cyclooctane] (18). The homoallylamine (6) has been cyclized into the 1-benzylspiro[pyrrolidine-2,1'-cyclooctane] (19).