159262-32-5 Usage
Uses
Used in Pharmaceutical Industry:
L-ANTI-ENDO-3,4-METHANOPYRROLIDINEDICARBOXYLIC ACID is used as a therapeutic agent for the treatment of neurodegenerative diseases due to its potent inhibition of L-glutamate uptake. This property allows it to potentially slow down or halt the progression of these diseases by modulating the levels of L-glutamate in the brain, which is often implicated in the pathogenesis of neurodegeneration.
Used in Research and Development:
L-ANTI-ENDO-3,4-METHANOPYRROLIDINEDICARBOXYLIC ACID is also used as a research tool in the development of new drugs and therapies targeting neurodegenerative conditions. Its ability to inhibit L-glutamate uptake can provide valuable insights into the underlying mechanisms of these diseases and help in the design of more effective treatments.
Biological Activity
Potent inhibitor of the Na + -dependent high-affinity synaptosomal glutamate transporter.
Check Digit Verification of cas no
The CAS Registry Mumber 159262-32-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,9,2,6 and 2 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 159262-32:
(8*1)+(7*5)+(6*9)+(5*2)+(4*6)+(3*2)+(2*3)+(1*2)=145
145 % 10 = 5
So 159262-32-5 is a valid CAS Registry Number.
159262-32-5Relevant academic research and scientific papers
Synthesis and biological evaluation of 6-carboxy-3,4-methanoprolines, new rigid glutamate analogs
Marinozzi,Natalini,Ni,Constantino,Pellicciari,Thomsen
, p. 327 - 331 (2007/10/02)
6-Carboxy-3,4-methanoprolines were prepared by reacting ethyl diazoacetate with the suitable 3,4-didehydroproline derivative in the presence of rhodium(II)acetate dimer as catalyst. The affinities of the title compounds for displacement of receptor binding to ionotropic and metabotropic (mGluR1α) glutamate receptors were also determined.
