1592892-06-2

Upstream product

• 402-43-7 p-trifluoromethylphenyl bromide 
• 123-54-6 acetylacetone 
• 1592891-99-0 4-hydroxy-4-(4-(trifluoromethyl)phenyl)pentan-2-one 
• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 96307-88-9 2-(4-Trifluoromethyl-phenyl)-pent-3-yn-2-ol 
• 1567646-56-3 C₁₂H₁₃F₃O 

Downstream Products

• 1592891-87-6 (Z)-2-phenyloct-2-en-4-yl acetate: 
• 1592891-20-7 (E)-4-(4-(trifluoromethyl)phenyl)pent-3-en-2-yl acetate 
• 1592890-33-9 (E)-1-(4-methylhepta-1,5-dien-4-yl)-4-(trifluoromethyl)benzene 

Relevant academic research and scientific papers

Alcohol Dehydrogenases and N-Heterocyclic Carbene Gold(I) Catalysts: Design of a Chemoenzymatic Cascade towards Optically Active β,β-Disubstituted Allylic Alcohols

The combination of gold(I) and enzyme catalysis is used in a two-step approach, including Meyer–Schuster rearrangement of a series of readily available propargylic alcohols followed by stereoselective bioreduction of the corresponding allylic ketone intermediates, to provide optically pure β,β-disubstituted allylic alcohols. This cascade involves a gold N-heterocyclic carbene and an enzyme, demonstrating the compatibility of both catalyst types in aqueous medium under mild reaction conditions. The combination of [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene][bis(trifluoromethanesulfonyl)-imide]gold(I) (IPrAuNTf2) and a selective alcohol dehydrogenase (ADH-A from Rhodococcus ruber, KRED-P1-A12 or KRED-P3-G09) led to the synthesis of a series of optically active (E)-4-arylpent-3-en-2-ols in good yields (65–86 %). The approach was also extended to various 2-hetarylpent-3-yn-2-ol, hexynol, and butynol derivatives. The use of alcohol dehydrogenases of opposite selectivity led to the production of both allyl alcohol enantiomers (93->99 % ee) for a broad panel of substrates.

Catalytic stereospecific allyl-allyl cross-coupling of internal allyl electrophiles with allylB(pin)

Application of internal electrophiles in catalytic stereospecific allyl-allyl cross-coupling enable the rapid construction of multisubstituted 1,5-dienes, including those with all carbon quaternary centers. Compounds with minimal steric differentiation ca