1592891-99-0

Upstream product

• 402-43-7 p-trifluoromethylphenyl bromide 
• 123-54-6 acetylacetone 
• 402-51-7 4-(trifluoromethyl)phenylmagnesium bromide 

Downstream Products

• 1592890-33-9 (E)-1-(4-methylhepta-1,5-dien-4-yl)-4-(trifluoromethyl)benzene 
• 1592891-87-6 (Z)-2-phenyloct-2-en-4-yl acetate: 
• 1567646-56-3 C₁₂H₁₃F₃O 
• 1592892-06-2 (R)-(E)-4-[4-(trifluoromethyl)phenyl]pent-3-en-2-ol 
• 1592891-20-7 (E)-4-(4-(trifluoromethyl)phenyl)pent-3-en-2-yl acetate 

Relevant academic research and scientific papers

Isopropylmagnesium chloride-promoted unilateral addition of Grignard reagents to β-diketones: One-pot syntheses of β-tertiary hydroxyl ketones or 3-substituted cyclic-2-enones

The regioselective unilateral additions of Grignard reagents to acyclic or cyclic β-diketones were effectively promoted by sub-stoichiometric amounts of i-PrMgCl to afford β-tertiary hydroxyl ketones or 3-substituted cyclic-2-enones, respectively. Also, the addition of Grignard reagents to acyclic β-diketones followed by a reaction with cyclic β-diketones in a one-pot process was put forward. The reaction mechanism was discussed in detail to explain the high regioselectivity via chemical experiments, hydrogen-deuterium exchange and mass spectrometry.

Catalytic stereospecific allyl-allyl cross-coupling of internal allyl electrophiles with allylB(pin)

Application of internal electrophiles in catalytic stereospecific allyl-allyl cross-coupling enable the rapid construction of multisubstituted 1,5-dienes, including those with all carbon quaternary centers. Compounds with minimal steric differentiation ca