159298-92-7Relevant academic research and scientific papers
A Lewis acid mediated schmidt reaction of benzylic azide: Synthesis of sterically crowded aromatic tertiary amines
Murali, Annamalai,Puppala, Manohar,Varghese, Babu,Baskaran, Sundarababu
, p. 5297 - 5302 (2011)
An efficient one-pot synthesis of sterically hindered aromatic tertiary amines through Lewis acid induced intermolecular Schmidt reaction of benzylic azides is described. In the presence of EtAlCl2, benzylic azide underwent a smooth Schmidt reaction to give the corresponding iminium ion, which, upon reduction with NaBH4 in situ, afforded the tertiary amine. The effects of substituents on the aromatic ring and the steric effects of the alkyl side chain have also been studied.
Synthesis of optically active 1-fluoroalkyl benzenes
Fritz-Langhals, Elke
, p. 1851 - 1854 (2007/10/02)
A simple synthesis of optically active 1-fluoroalkyl benzenes bearing electron withdrawing substituents is developed. Optically active 1- hydroxyalkyl benzenes are converted into the methanesulfonates and subsequently converted into the optically active 1-fluoroalkyl benzenes 1 by use of the fluorinating agent cesium fluoride/N-methyl-formamide.
