159301-43-6Relevant articles and documents
The microwave spectrum of an unstable molecule: Chloroketene ClHCCO
Gerry, M. C. L.,Lewis-Bevan, W.,Westwood, N. P. C.
, p. 4655 - 4663 (1983)
The microwave spectra of four isotopic species of the unstable molecule chloroketene ClHCCO have been observed from the flow pyrolysis of monochloroacetyl chloride and from the pyrolityc reaction of dichloroacetyl chloride with zinc metal.The spectra, which consist only of b-type transitions, were observed in the frequency range 26.5-80 GHz.Accurate rotational constants and quartic and sextic centrifugal distortion constants have been obtained for all isotopes.Large numbers of perturbations have been observed in the chlorine quadrupole hyperfine structure; consequently, the complete quadrupole coupling tensor has been evaluated.The dipole moment has been measured.The molecule has been shown to be planar, and a partial r0 structure has been determined.
COMPOUNDS THAT ARE ERK INHIBITORS
-
Page/Page column 296, (2009/10/18)
Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts, and solvates thereof. Q is a tetrahydopyridinyl ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
Efficient routes to isotopically labelled epichlorohydrins ((chloromethyl) oxiranes)
O'Hagan,White,Jones
, p. 871 - 880 (2007/10/02)
Efficient routes are developed for the synthesis of variously labelled 2H- and 13C- labelled epichlorohydrins prepared from appropriately labelled acetic acids and sodium borodeuteride. The route is versatile and can be used for strategic location of isotopes at C-I, C-2 and C-3 of epichlorohydrin. By way of demonstration [2-13C]-, [2-2H]-, [3-2H2] and [2-2H, 3-2H2]-epithlorohydrins have been prepared. In addition the syntheses can be adapted for the preparation of enantiomerically pure and isotopically labelled epichlorohydrins.