1593268-01-9Relevant academic research and scientific papers
Palladium-catalyzed carbonylative sonogashira coupling of aryl bromides using near stoichiometric carbon monoxide
Neumann, Karoline T.,Laursen, Simon R.,Lindhardt, Anders T.,Bang-Andersen, Benny,Skrydstrup, Troels
supporting information, p. 2216 - 2219 (2014/05/06)
A general procedure for the palladium-catalyzed carbonylative Sonogashira coupling of aryl bromides is reported, using near stoichiometric amounts of carbon monoxide. The method allows a broad substrate scope in moderate to excellent yields. The formed alkynone motive serves as a platform for synthesis of various heterocyclic structures, including pyrimidines. Furthermore, the presented strategy allows effective 13C labeling.
