182344-63-4

Basic information

• Product Name: N-(5-bromo-pyridin-2-yl)-2,2-dimethyl-propionamide
• Synonyms: N-(5-bromo-pyridin-2-yl)-2,2-dimethyl-propionamide;N-(5-Bromopyridin-2-Yl)Pivalamide;Propanamide, N-(5-bromo-2-pyridinyl)-2,2-dimethyl-
• CAS NO: 182344-63-4
• Molecular Formula: C₁₀H₁₃BrN₂O
• Molecular Weight: 257
• Mol File: 182344-63-4.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(5-bromo-pyridin-2-yl)-2,2-dimethyl-propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-bromo-pyridin-2-yl)-2,2-dimethyl-propionamide(182344-63-4)
• EPA Substance Registry System: N-(5-bromo-pyridin-2-yl)-2,2-dimethyl-propionamide(182344-63-4)

Safety Data

• Hazardous Substances Data: 182344-63-4(Hazardous Substances Data)

Usage

General Description

N-(5-bromo-pyridin-2-yl)-2,2-dimethyl-propionamide is a chemical compound with the molecular formula C11H14BrN3O. It is a white to off-white solid that is primarily used as a building block in organic synthesis. N-(5-bromo-pyridin-2-yl)-2,2-dimethyl-propionamide is classified as an amide, containing a pyridine ring and a bromine substituent. It has a molecular weight of 294.15 g/mol. N-(5-bromo-pyridin-2-yl)-2,2-dimethyl-propionamide may be used in pharmaceutical research or as a reagent in chemical reactions to synthesize more complex organic compounds. Additionally, it may have potential applications in the development of new drugs or materials.

Upstream product

• 1072-97-5 5-bromo-2-pyridylamine 
• 3282-30-2 pivaloyl chloride 
• 696-15-1 2-amino-5-bromopyridine N-oxide 
• 75-98-9 Trimethylacetic acid 
• 1538-75-6 2,2-dimethylpropanoic anhydride 

Downstream Products

• 207926-28-1 N-(5-acetyl-pyridin-2-yl)-2,2-dimethyl-propionamide 
• 207922-54-1 N-(5-Vinyl-pyridin-2-yl)-2.2-dimethylpropionamide 
• 1198408-35-3 6-amino-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1'-carboxylic acid tert-butyl ester 
• 1593268-01-9 N-(5-(3-(4-(tert-butyl)phenyl)prop-2-ynoyl)pyridin-2-yl)pivalamide 

Relevant articles and documents

Synthesis of micrococcinic acid

The first synthesis of micrococcinic acid (2) is described. The five rings of 2 are assembled from monocyclic precursors using four palladium-catalyzed biaryl coupling reactions.

Discovery of novel Bcr-Abl inhibitors with diacylated piperazine as the flexible linker

Forty-two compounds (series 8, 9 and 10) incorporated with diacylated piperazine have been synthesized and evaluated as novel Bcr-Abl inhibitors based on 'six-atom linker'. Five of them, 8d, 8h, 8l, 10m and 10p, displayed potent Bcr-Abl inhibitory activity comparable with Imatinib. Moreover, compounds 8e, 10q, 10s, and 10u were potent Bcr-Abl inhibitors with IC50 values at the sub-micromolecular level. Most compounds exhibited moderate to high antiproliferative activity against K562 cells. In particular, compound 9e was the most promising Bcr-Abl inhibitor. Docking studies revealed that the binding modes of these compounds were similar with Imatinib. These compounds could be considered as promising lead compounds for further optimization.

Rapid and selective in situ reduction of pyridine- N -oxides with tetrahydroxydiboron

Pyridine-N-oxides are often used as reactive precursors in the syntheses of substituted pyridines. Isolation and subsequent reduction of the associated pyridine-N-oxide intermediates can be challenging. We have discovered that tetrahydroxydiboron functions as a mild, versatile, and remarkably selective reducing agent for pyridine-N-oxides and may be used in an in situ fashion, thus obviating the isolation of N-oxide-containing intermediates. Georg Thieme Verlag Stuttgart New York.