15936-11-5

Usage

Class

1,8-Naphthyridines

Explanation

1,8-Naphthyridin-2(1H)-one,1-methyl-(8CI,9CI) belongs to a class of heterocyclic aromatic compounds known as 1,8-naphthyridines, which are characterized by a fused six-membered and seven-membered ring system containing nitrogen.

Explanation

These are alternative names for the compound, which can be used interchangeably to refer to the same chemical structure.

Explanation

The compound features a naphthyridine ring system with a methyl group (CH3) attached to one of the nitrogen atoms in the ring.
5. Heterocyclic aromatic compound

Explanation

This term describes a type of organic compound that contains a ring of atoms with at least one heteroatom (an atom other than carbon), in this case, nitrogen.
6. Pharmaceutical synthesis

Explanation

The compound is used in the synthesis of pharmaceutical compounds, which are chemicals used for medicinal purposes.
7. Potential biological activities

Explanation

The compound may have biological activities, which means it could interact with living organisms and potentially have an effect on their biological processes.
8. Safety precautions

Explanation

It is important to handle 1,8-Naphthyridin-2(1H)-one,1-methyl-(8CI,9CI) with care and follow proper safety precautions when working with or synthesizing it to minimize the risk of harm to the user and the environment.

Synonyms

1-methyl-1,8-naphthyridin-2(1H)-one, 1-methylquinolin-2(1H)-one

Structure

Methyl group attached to the nitrogen atom of the naphthyridine ring

Upstream product

• 37960-59-1 1-methyl-1,8-naphthyridinium iodide 
• 103976-57-4 1,2-dihydro-2-imino-1-methyl-1,8-naphthyridine 
• 103976-54-1 2-amino-1,2-dihydro-1-methyl-1,8-naphthyridine 

Relevant academic research and scientific papers

Visible-Light-Mediated Aerobic Oxidation of N-Alkylpyridinium Salts under Organic Photocatalysis

Quinolones and isoquinolones exhibit diverse biological and pharmaceutical activities, and their synthesis is highly desirable under mild conditions. Here, a highly efficient and environmentally friendly visible light-mediated aerobic oxidation of readily available N-alkylpyridinium salts has been developed with Eosin Y as the organic photocatalyst and air as the terminal oxidant, and the reaction provided quinolones and isoquinolones in good yields. The method shows numerous advantages including mild and environmentally friendly conditions, high efficiency, tolerance of wide functional groups and low cost. Furthermore, 4-desoxylonimide with important pharmaceutical activities was effectively prepared by using our method. Therefore, the present method should provide a novel and useful strategy for synthesis and modification of N-heterocycles.

Imination of N-Methylazinium Salts by Liquid Ammonia/Potassium Permanganate

Treatment of 1-methylquinolinium-, 1,4-dimethylquinolinium- and 1-methyl-1,X-naphthyridinium iodides (X=5,8) with liquid ammonia/potassium permanganate leads to introduction of the imino group at C-2 forming the 1,2-dihydro-2-imino-1-methylquinolines and 1,2-dihydro-2-imino-1-methyl-1,X-naphthyridines (X=5,8) respectively. 1,2-Dimethylquinolinium iodide, when subjected to treatment with liquid ammonia/potassium permanganate undergoes an oxo-demethylation reaction, yielding 1-methylquinol-2-one.The nmr-measurements of solutions of the above-mentioned salts in liquid ammonia clearly show the formation of ?-adduct, strongly suggesting that these ?-adducts are intermediates in the imination reactions.