15937-10-7

Usage

Uses

Used in Organic Synthesis:
1-Acetyl-5,6-dimethoxyindoline is used as a building block in organic synthesis for its unique chemical structure, which can be further modified or incorporated into more complex molecules for various applications.
Used in Pharmaceutical Research:
1-Acetyl-5,6-dimethoxyindoline is used as a research compound in pharmaceutical research to explore its potential biological activities and pharmacological properties, with the aim of developing new drugs or therapeutic agents.
Used in Chemical Industry:
1-Acetyl-5,6-dimethoxyindoline is used as an intermediate in the chemical industry for the production of other compounds, taking advantage of its reactivity and functional groups.
Used in Research and Development:
1-Acetyl-5,6-dimethoxyindoline is used as a subject of study in research and development to understand its properties, potential applications, and to innovate new uses across various industries.

Upstream product

• 74064-26-9 N-[2-(2-bromo-4,5-dimethoxyphenyl)ethyl]acetamide 
• 6275-29-2 N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide 
• 66384-45-0 N-acetyl-2-iodo-4,5-dimethoxy-β-phenethylamine 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 

Downstream Products

• 14430-23-0 5,6-dimethoxyindole 
• 29539-03-5 5,6-dihydroxy-indoline 
• 138937-28-7 5,6-dihydroxyindoline hydrobromide 

Relevant academic research and scientific papers

Preparation method of compound 5,6-dihydroxy indoline and halogen acid salts thereof

The invention relates to a preparation method of a compound 5,6-dihydroxy indoline and halogen acid salts thereof. Phenylethylamine SM-0 sold in the market is used as a raw material and firstly reactswith acyl chloride to obtain amide SM-1; amide SM-1 rea

Phosphane-free Pd0-catalyzed cycloamination and carbonylation with Pd(OAc)2 and Cu(OAc)2 in the presence of K 2CO3: Preparation of benzocyclic amines and benzolactams

Phosphane-free Pd0-catalyzed intramolecular aromatic amination was studied. o-Halophenethylamines and 3-(o-halophenyl)propylamines were found to be transformed into indolines and quinolines in a catalytic system based on Pd(OAc)2 and Cu(OAc)2 in the presence of K 2CO3. Application of the method to substrates containing isoquinoline rings- the 1-(o-bromobenzyl)-3,4-dihydroisoquinolines 6, the 1-(o-bromobenzyl)-1,2,3,4-tetrahydroisoquinolines 7, and the 1-(o-bromophenethyl)isoquinolines 9- provided the indolo[2,1-a]isoquinoline and dibenzo[a,f]quinolizine ring systems 8 and 10. Extension of the method to β-carbolines (compounds 11, 12, and 17) produced the benz[f]indolo[2,3-a] indolizine-13-ones 15 and the benz[f]indolo[2,3-a]quinolizine 18. The benzo[f]pyrido[3,4-a]indolizine and indolo[f]pyrido[3,4-a]indolizin-12-one ring systems 27 and 31 were built in a similar manner. It was also found that under an atmosphere of CO the same catalytic system produced the corresponding benzolactams, the isoquino[2,1-a][2,7]naphthyridine 34 and the indolo[2,3-a]pyrido[g]quinolizin-8-one 36 [(±)-dihydronauclefine] in good yields. Copyright

Studies on the Syntheses of Heterocyclic Compounds. Part 865. A Novel Synthesis of Indole Derivatives by Intramolecular Nucleophilic Aromatic Substitution

Cyclisation of N-(2-bromo-4,5-dimethoxyphenethyl)acetamide (6) afforded 1-acetyl-2,3-dihydro-5,6-dimethoxy-1H-indole (13) by intramolecular nucleophilic aromatic substitution using sodium hydride and cuprous halide in dimethylformamide.The dihydroindoles (14), (15), and (16) were also synthesised from the corresponding amides (8) and (10) and the carbamate (12) in a similar manner.The dihydroindoles (13), (14), and (16) were converted into the indoles (20) and (21) in excellent yield by oxidation and subsequent alkaline hydrolysis.The 2-oxindoles (26) and (27) were also prepared under similar reaction condition from the phenylacetamide (24) and (25).

A NOVEL SYNTHESIS OF INDOLE DERIVATIVES

1-Acetyl-2,3-dihydro-5,6-dimethoxy-1H-indole (13) was synthesized by cyclization of N-(2-bromo-4,5-dimethoxyphenethyl)acetamide (6) using sodium hydride and cuprous halide in dimethylformamide.Indoles (14,15 and 16) were prepared in a similar manner from