15938-72-4

Basic information

• Product Name: Coumarin
• Synonyms: 3,3'-(3,4,5-TRIMETHOXYBENZYLIDENE)BIS(4-HYDROXYCOUMARIN)
• CAS NO: 15938-72-4
• Molecular Formula: C₂₈H₂₂O₉
• Molecular Weight: 146.14274
• Mol File: 15938-72-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 666.2°Cat760mmHg
• Flash Point: 223.2°C
• Appearance: /
• Density: 1.461g/cm³
• CAS DataBase Reference: Coumarin(CAS DataBase Reference)
• NIST Chemistry Reference: Coumarin(15938-72-4)
• EPA Substance Registry System: Coumarin(15938-72-4)

Safety Data

• Hazardous Substances Data: 15938-72-4(Hazardous Substances Data)

Upstream product

• 22105-09-5 4‐hydroxycoumarin 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 1076-38-6 4-hydroxy[1]benzopyran-2-one 

Downstream Products

• 375359-23-2 7-(3,4,5-trimethoxy-phenyl)-4aH-pyrano[3,2-c:5,6-c']dichromene-6,8-dione 

Relevant articles and documents

Camphor sulfonic acid catalyzed facile and general method for the synthesis of 3,3'-(arylmethylene)bis(4-hydroxy-2H-chromen-2-ones), 3,3'-(arylmethylene)bis(2-hydroxynaphthalene-1,4-diones) and 3,3'-(2-oxoindoline-3,3-diyl)bis(2-hydroxynaphthalene-1,4-dio

Camphor sulfonic acid catalyzed a straightforward, efficient, and general method has been developed for the synthesis of 3,3'-(arylmethylene)bis(4-hydroxy-2H-chromen-2-ones), 3,3'-(arylmethylene)bis(2-hydroxynaphthalene-1,4-diones) and 3,3'-(2-oxoindoline

Thiamine hydrochloride as a recyclable organocatalyst for the synthesis of bis(indolyl)methanes, tris(indolyl)methanes, 3,3-di(indol-3-yl)indolin-2-ones and biscoumarins

Thiamine hydrochloride was identified as an eco-friendly organocatalyst for the synthesis of a broad range of bis(indolyl)methanes in good to excellent yields. Green chemistry matrix calculations showed high atom economy and a small E-factor for the reaction. Moreover, the simple and easy operational protocol using a small amount of thiamine hydrochloride (1 mol%) makes this procedure an alternative approach for this transformation industrially. This protocol was also extended to the synthesis of naturally occurring alkaloids such as tris(indolyl)methane, arundine, vibrindole A, 3,3-di(indol-3-yl)indolin-2-ones and biscoumarin derivatives.

Ca(II)-catalyzed, one-pot four component synthesis of functionally embellished benzylpyrazolyl coumarins in water

A facile one-pot, four-component synthesis of biologically important benzylpyrazolyl coumarins in water has been demonstrated using environmentally benign Ca(II) as the catalyst. Participation of aliphatic aldehydes has been described for the first time. Short reaction times, high yields and chromatography free isolation of the products, usage of eco-friendly catalyst and solvent are the key features of this method.