159388-77-9Relevant academic research and scientific papers
A new entry to the construction of a quaternary carbon center having a fluorine atom - SN2′ reaction of γ-fluoroallylic alcohol derivatives with various cyanocuprates
Konno, Tsutomu,Ikemoto, Atsushi,Ishihara, Takashi
, p. 8154 - 8163 (2012/10/30)
Treatment of γ-fluoroallylic phosphate with various lower-ordered cyanocuprates derived from Grignard reagents, organolithium, and organozincs gave the corresponding SN2′ products having a fluorine atom at a quaternary carbon center in excellent yields. This system could be successfully extended to the chiral version, enantiomerically pure fluorine-containing materials also being obtained in high yield.
