1462-75-5

Basic information

• Product Name: 3-PHENYL PROPANE MAGNESIUM BROMIDE
• Synonyms: 3-PHENYL PROPANE MAGNESIUM BROMIDE;3-Phenyl-1-propylmagnesium bromide, 0.5M THF
• CAS NO: 1462-75-5
• Molecular Formula: C₉H₁₁BrMg
• Molecular Weight: 0
• Mol File: 1462-75-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: 3-PHENYL PROPANE MAGNESIUM BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PHENYL PROPANE MAGNESIUM BROMIDE(1462-75-5)
• EPA Substance Registry System: 3-PHENYL PROPANE MAGNESIUM BROMIDE(1462-75-5)

Safety Data

• Hazardous Substances Data: 1462-75-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H11.BrH.Mg/c1-2-6-9-7-4-3-5-8-9;;/h3-5,7-8H,1-2,6H2;1H;/q;;+1/p-1/rC9H11BrMg/c10-11-8-4-7-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2

Upstream product

• 637-59-2 1-Bromo-3-phenylpropane 
• 7439-95-4 magnesium 

Downstream Products

• 10521-91-2 5-phenylpentan-1-ol 
• 122649-74-5 (1-benzo[1,3]dioxol-5-yl-4-phenyl-butyl)-dibutyl-amine 
• 102372-17-8 4-(4-Phenyl-1-piperidino-butyl)-phenol 
• 10473-01-5 methyl 4-phenylbutyl ether 
• 60012-62-6 phenyl-1 hexanol-2 
• 1588-44-9 6-phenyl-1-hexene 
• 52376-43-9 1-methyl-1-phenyl-1,2,3,4-tetrahydronaphthalene 
• 2979-70-6 2-methyl-5-phenyl-2-pentanol 
• 18677-35-5 Methyl-bis-<3-phenyl-propyl-(1)>-silan 
• 64957-77-3 3-Methoxy-2-(3-phenyl-propyl)-benzoic acid 
• 31067-15-9 1,1,4-triphenyl-1-butanol 
• 1718-50-9 1,5-diphenylpentane 
• 58978-27-1 2,5-diphenylpentan-2-ol 
• 132777-02-7 4-phenyl-1-<4-(trifluoromethyl)phenyl>butan-1-ol 

Relevant articles and documents

Titanium isopropoxide-mediated cis-selective synthesis of 3,4-substituted butyrolactones from CO2

We report a Ti(OiPr)4-mediated multicomponent reaction, which produces 3,4-substituted cis-δ-lactones from alkyl magnesium chloride, benzaldehyde and CO2. The key intermediate, titanacyclopropane, is formed in situ from Ti(OiPr)4 and a Grignard reagent, which enables 1,2-dinucleophilic reactivity that is used to insert carbon dioxide and an aldehyde. An alternative reaction route is also described where a primary alkene is used to create the titanacyclopropane. A computational analysis of the elementary steps shows that the carbon dioxide and the aldehyde insertion proceeds through an inner-sphere mechanism. A variety of cis-butyrolactones can be synthesized with up to 7?:?1 diastereoselectivity and 77% yield.

Indolone derivative as well as preparation method and application thereof

The invention relates to a compound represented by formula (A) or a pharmaceutically acceptable salt, a stereoisomer, a tautomer, a polymorphic substance, a solvate, a metabolite or a prodrug thereof,and also relates to a pharmaceutical composition containing the compound. The compound can be used for treating cancer or immune system diseases.

Iron-Catalyzed Cross-Coupling of Alkynyl and Styrenyl Chlorides with Alkyl Grignard Reagents in Batch and Flow

Transition-metal-catalyzed cross-coupling chemistry can be regarded as one of the most powerful protocols to construct carbon–carbon bonds. While the field is still dominated by palladium catalysis, there is an increasing interest to develop protocols that utilize cheaper and more sustainable metal sources. Herein, we report a selective, practical, and fast iron-based cross-coupling reaction that enables the formation of Csp?Csp3 and Csp2?Csp3 bonds. In a telescoped flow process, the reaction can be combined with the Grignard reagent synthesis. Moreover, flow allows the use of a supporting ligand to be avoided without eroding the reaction selectivity.