159391-85-2Relevant academic research and scientific papers
Synthesis and biological evaluation of [D-lysine]8cyclosporin A analogs as potential anti-HCV agents
Scribner, Andrew,Houck, David,Huang, Zhuhui,Mosier, Sarah,Peel, Michael,Scorneaux, Bernard
scheme or table, p. 6542 - 6546 (2010/12/20)
An efficient synthesis of [d-lysine]8cyclosporin A has been developed. Several analogs of [d-lysine]8cyclosporin A have been synthesized and show promising anti-HCV activity, particularly compounds 39 and 43, which each exhibit an anti-HCV EC50 200 nM, and are each ≥50-fold less immunosuppressive than cyclosporin A.
Cyclosporin A: Regioselective Ring Opening and Fragmentation Reactions via Thioamides. A Route to Semisynthetic Cyclosporins
Eberle, Marcel K.,Jutzi-Eme, Anne-Marie,Nuninger, Francois
, p. 7249 - 7258 (2007/10/02)
Cyclosporin A (1a) served as the starting material for the semisynthetic preparation of a variety of novel cyclosporins.Acetylcyclosporin A (2) was treated with Lawesson's reagent.From the reaction mixture, three novel acetylated thioamides were isolated:
