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1594094-64-0

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1594094-64-0 Usage

Description

CW069 is an allosteric inhibitor of KIFC/HSET (IC50 = 75 μM), a microtubule motor protein involved in bipolar spindle assembly and centrosome clustering. It increases the number of multipolar spindles in N1E-115 mouse neuroblastoma cells with supernumerary centrosomes when used at concentrations of 100 and 200 μM, without affecting the morphology of mitotic spindles in normal human dermal fibroblast (NHDF) cells. CW069 inhibits proliferation of N1E-115, but not NHDF, cells (IC50s = 86 and 181 μM, respectively).

Uses

CW 069 is an allosteric inhibitor of the microtubule motor protein HSET which induces multipolar mitoses only in cells containg supernumerary centrosomes.

references

[1]. watts ca, richards fm, bender a, et al. design, synthesis, and biological evaluation of an allosteric inhibitor of hset that targets cancer cells with supernumerary centrosomes. chem biol, 2013, 20(11): 1399-1410.

Check Digit Verification of cas no

The CAS Registry Mumber 1594094-64-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,5,9,4,0,9 and 4 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1594094-64:
(9*1)+(8*5)+(7*9)+(6*4)+(5*0)+(4*9)+(3*4)+(2*6)+(1*4)=200
200 % 10 = 0
So 1594094-64-0 is a valid CAS Registry Number.

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