159417-92-2Relevant articles and documents
PYRAZOLE-OXAZOLIDINONE COMPOUND FOR ANTI-HEPATITIS B VIRUS
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Paragraph 0342; 0345-0346, (2019/06/07)
The present invention discloses a pyrazole-oxazolidinone compound having anti-hepatitis B virus activity, which has the structure of formula (I), wherein each variable is as defined herein.
Design and synthesis of isoquinolines and benzimidazoles as RAF kinase inhibitors
Buchstaller, Hans-Peter,Burgdorf, Lars,Finsinger, Dirk,Stieber, Frank,Sirrenberg, Christian,Amendt, Christiane,Grell, Matthias,Zenke, Frank,Krier, Mireille
, p. 2264 - 2269 (2011/05/15)
RAF kinase plays a critical role in the RAF-MEK-ERK signaling pathway and inhibitors of RAF could be of use for the treatment of various cancer types. We have designed potent RAF-1 inhibitors bearing novel bicyclic heterocycles as key structural elements for the interaction with the hinge region. In both series exploration of the SAR was focussed on the substitution of the phenyl ring, which binds to the induced fit pocket. Overall, it was confirmed that incorporation of lipophilic substituents was needed for potent Raf inhibition and a number of potent analogues were obtained.
Design, synthesis and properties of several heterocyclic dopaminergic ligands
Kostic,Soskic,Joksimovic
, p. 697 - 702 (2007/10/02)
Two series of non-catechol dopamine (DA) bioisosteres with the hydroxyl groups on the benzene ring replaced by N-H groups were synthesized using phenethylamine as a parent molecule. Compounds from the first series (1-9) contained a primary amine group, wh
