159423-46-8

Basic information

• Product Name: 1-<3,4-di-(t-butyldimethylsilyloxy)-phenyl>-1-oxo-propanone-1,3-propylenedithioacetal
• Synonyms: 1-<3,4-di-(t-butyldimethylsilyloxy)-phenyl>-1-oxo-propanone-1,3-propylenedithioacetal
• CAS NO: 159423-46-8
• Molecular Weight: 498.899
• Mol File: 159423-46-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-<3,4-di-(t-butyldimethylsilyloxy)-phenyl>-1-oxo-propanone-1,3-propylenedithioacetal(CAS DataBase Reference)
• NIST Chemistry Reference: 1-<3,4-di-(t-butyldimethylsilyloxy)-phenyl>-1-oxo-propanone-1,3-propylenedithioacetal(159423-46-8)
• EPA Substance Registry System: 1-<3,4-di-(t-butyldimethylsilyloxy)-phenyl>-1-oxo-propanone-1,3-propylenedithioacetal(159423-46-8)

Safety Data

• Hazardous Substances Data: 159423-46-8(Hazardous Substances Data)

Upstream product

• 139-85-5 3,4-dihydroxybenzaldehyde 
• 108378-67-2 2-(3,4-dihydroxyphenyl)-1,3-propylenedithioacetal 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 108-24-7 acetic anhydride 
• 159423-45-7 2-<3,4-di-(t-butyldimethylsilyloxy)-phenyl>-1,3-propylenedithioacetal 

Downstream Products

• 159423-48-0 1-<3,4-di-(t-butyldimethylsilyloxy)-phenyl>-2-propanol 
• 84678-97-7 1-(3,4-dihydroxyphenyl)-2-propanol 
• 2503-44-8 1-(3,4-dihydroxyphenyl)-2-propanone 
• 159423-47-9 1-<3,4-di-(t-butyldimethylsilyloxy)-phenyl>-2-propanone 

Relevant articles and documents

The synthesis of 1-(3,4-dihydroxyphenyl)-2-propanone and 1-(3,4-dihydroxyphenyl)-2-propanol

Acetylation of 1,3-propylenedithioacetal of 3,4-dihydroxybenzaldehyde silyl ether 5 followed by reductive desulfurization of the masking group gave ketone 7 which was reduced to alcohol 8. Hydrolysis of the silyl protecting groups in 7 and 8 afforded the title compounds which were metabolites of 1-(4-hydroxy-3-methoxyphenyl)-2-propanone, found in smoked meat.