84678-97-7

Upstream product

• 108378-67-2 2-(3,4-dihydroxyphenyl)-1,3-propylenedithioacetal 
• 16047-57-7 (((4-bromo-1,2-phenylene)bis(oxy))bis(methylene))dibenzene 
• 159423-47-9 1-<3,4-di-(t-butyldimethylsilyloxy)-phenyl>-2-propanone 
• 159423-48-0 1-<3,4-di-(t-butyldimethylsilyloxy)-phenyl>-2-propanol 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 159423-46-8 1-<3,4-di-(t-butyldimethylsilyloxy)-phenyl>-1-oxo-propanone-1,3-propylenedithioacetal 
• 159423-45-7 2-<3,4-di-(t-butyldimethylsilyloxy)-phenyl>-1,3-propylenedithioacetal 

Relevant academic research and scientific papers

An optically active isochroman-2H-chromene conjugate potently suppresses neuronal oxidative injuries associated with the PI3K/Akt and MAPK signaling pathways

Increasing evidence suggests that the use of potent neuroprotective agents featured with novel pharmacological mechanism would offer a promising strategy to delay or prevent the progression of neurodegeneration. Here, we provide the first demonstration that the chiral nonracemic isochroman-2H-chromene conjugate JE-133, a novel synthetic 1,3-disubstituted isochroman derivative, possesses superior neuroprotective effect against oxidative injuries. Pretreatment with JE-133 (1–10 μM) concentration-dependently prevented H2O2-induced cell death in SH-SY5Y neuroblastoma cells and rat primary cortical neurons. Pretreatment with JE-133 significantly alleviated H2O2-induced apoptotic changes. These protective effects could not be simply attributed to the direct free radical scavenging as JE-133 had moderate activity in reducing DPPH free radical. Further study revealed that pretreatment with JE-133 (10 μM) significantly decreased the phosphorylation of MAPK pathway proteins, especially ERK and P38, in the neuronal cells. In addition, blocking PI3K/Akt pathway using LY294002 partially counteracted the cell viability-enhancing effect of JE-133. We conclude that JE-133 exerts neuroprotection associated with dual regulative mechanisms and consequently activating cell survival and inhibiting apoptotic changes, which may provide important clues for the development of effective neuroprotective drug lead/candidate.

The synthesis of 1-(3,4-dihydroxyphenyl)-2-propanone and 1-(3,4-dihydroxyphenyl)-2-propanol

Acetylation of 1,3-propylenedithioacetal of 3,4-dihydroxybenzaldehyde silyl ether 5 followed by reductive desulfurization of the masking group gave ketone 7 which was reduced to alcohol 8. Hydrolysis of the silyl protecting groups in 7 and 8 afforded the title compounds which were metabolites of 1-(4-hydroxy-3-methoxyphenyl)-2-propanone, found in smoked meat.

Hair dyeing composition containing an aryldiamine and a substituted catechol

A composition for use in the dyeing of keratinous fibre such as hair includes an aqueous anaerobic solution of an aryldiamine and a substituted catechol. Optionally, an aromatic coupling agent can also be incorporated in the composition to modify the shade of color produced. Anaerobic storage conditions can, for example, be maintained by packing the composition in an aerosol container with a halocarbon propellant.