159490-55-8

Usage

Uses

Used in Pharmaceutical Industry:
Ketoprofen-D3 is used as an internal standard for the quantification of Ketoprofen in pharmaceutical applications. It aids in the accurate measurement of Ketoprofen levels in various formulations, ensuring the quality and efficacy of the drug.
Used in Research and Development:
In the field of research and development, Ketoprofen-D3 serves as an essential tool for the analysis of Ketoprofen in biological samples. It helps researchers to study the pharmacokinetics, pharmacodynamics, and metabolism of Ketoprofen, contributing to the development of new drugs and therapies.
Used in Quality Control:
Ketoprofen-D3 is utilized in quality control processes to ensure the consistency and potency of Ketoprofen-containing products. By using Ketoprofen-D3 as an internal standard, laboratories can accurately determine the concentration of Ketoprofen in samples, ensuring that the products meet the required standards and specifications.
Used in Toxicology and Forensic Analysis:
In toxicology and forensic analysis, Ketoprofen-D3 is employed as an internal standard for the detection and quantification of Ketoprofen in various biological samples, such as blood, urine, and tissue. This helps in the investigation of drug overdoses, drug-facilitated crimes, and other related cases.

Upstream product

• 865-50-9 iodomethane-d3 
• 80073-58-1 dimethyl 2-(3'-benzoyl)phenylpropanedioate 
• 75116-77-7 diethyl 2-(3-benzoylphenyl)malonate 
• 1016-77-9 3-bromobenzophenone 
• 159490-44-5 (3-benzoyl)phenylazo tert-butyl sulfide 
• 2835-78-1 3-amino benzophenone 
• 71-43-2 benzene 
• 121-90-4 m-nitrobenzoic acid chloride 
• 2243-80-3 3-nitrobenzophenone 

Relevant academic research and scientific papers

The Effects of Prodrug Size and a Carbonyl Linker on l-Type Amino Acid Transporter 1-Targeted Cellular and Brain Uptake

The l-type amino acid transporter 1 (LAT1, SLC7A5) imports dietary amino acids and amino acid drugs (e. g., l-DOPA) into the brain, and plays a role in cancer metabolism. Though there have been numerous reports of LAT1-targeted amino acid-drug conjugates (prodrugs), identifying the structural determinants to enhance substrate activity has been challenging. In this work, we investigated the position and orientation of a carbonyl group in linking hydrophobic moieties including the anti-inflammatory drug ketoprofen to l-tyrosine and l-phenylalanine. We found that esters of meta-carboxyl l-phenylalanine had better LAT1 transport rates than the corresponding acylated l-tyrosine analogues. However, as the size of the hydrophobic moiety increased, we observed a decrease in LAT1 transport rate with a concomitant increase in potency of inhibition. Our results have important implications for designing amino acid prodrugs that target LAT1 at the blood-brain barrier or on cancer cells.

A comparative study on the photo-induced arylation of β-dicarbonyl compounds by arylazosulfides and its use in the synthesis of methyl labeled 2-arylpropionic acids

A comparative study on the arylation of β-dicarbonyl derivatives (acetylacetone, methyl acetoacetate and dimethyl malonate) by using the photo-induced decomposition of arylazosulfides is presented. The arylazosulfides used contained the aryl moieties related to Ketoprofen or Ibuprofen and the reaction was performed following the procedure reported by Dell'Erba et al. (Tetrahedron, 1991, 47, 333). From the arylazosulfides assayed, only those bearing a carbonyl group attached to the benzene ring, i.e. 1 and 11, afforded the corresponding arylation adducts in satisfactory yields. Concerning the β-dicarbonyl derivatives, condensation of acetylacetone in the case of 1 and of dimethyl malonate in that of 11 gave the best results. However, the further methylation of the aryl β-dicarbonyl adduct was clearly advantageous for the case of the 2-arylmalonate derivatives. The use of this synthetic strategy for the convenient preparation of Ketoprofen (23% overall yield, 7 steps from 3-nitrobenzophenone) and Ibuprofen (34% overall yield, 8 steps from 4-isobutyrylbenzene) isotopomers labeled at the methyl group at C-2 is also reported.