1595-73-9

Upstream product

• 51738-12-6 4-Iod-1-phenyl-3-hexen-1-in-5-on 
• 1595-56-8 6-phenyl-3,5-hexadiyne-2-ol 
• 879560-02-8 (1,1-dibromobut-1-en-3-yn-2-yl)benzene 
• 75-36-5 acetyl chloride 
• 2579-22-8 Phenylpropargyl aldehyde 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 52688-12-7 4-Brom-1-phenyl-3-hexen-1-in-5-on 

Relevant academic research and scientific papers

Gold-Catalyzed Oxidative Cyclization Involving Nucleophilic Attack to the Keto Group of α,α′-Dioxo Gold Carbene and 1,2-Alkynyl Migration: Synthesis of Furan-3-carboxylates

A multicomponent strategy for the synthesis of functionalized furan-3-carboxylates based on gold-catalyzed oxidative cyclization of diynones with alcohols or water has been developed. Mechanistic studies revealed that a rare nucleophilic attack to the carbonyl group of the α,α′-dioxo gold carbene instead of the carbene center and 1,2-alkynyl group migration were involved in this transformation. This method offers several advantages such as mild conditions, high regio- and chemoselectivity, and wide functional group compatibility.

Asymmetric reduction of Diynones and the total synthesis of (S)-Panaxjapyne A

The asymmetric transfer hydrogenation of a series of diynones has been achieved in high conversion and enantiomeric induction. When R1 is a phenyl group, a competing alkyne reduction takes place; however, when R 1 is an alkyl group, this side-reaction is not observed. The application of the reduction to the total synthesis of the natural product (S)-panaxjapyne A in high enantiomeric excess is described.

One-pot formation and derivatization of di- and triynes based on the Fritsch-Buttenberg-Wiechell rearrangement

(Chemical Equation Presented) A divergent, one-pot synthesis of functionalized polyynes has been developed. Beginning with the appropriately substituted dibromoolefinic precursor, a carbenoid Fritsch-Buttenberg-Wiechell (FBW) rearrangement is used to gene

A one-pot synthesis and functionalization of polyynes

A one-pot synthesis and derivatization of diynes and triynes is reported. The polyyne framework is formed from a dibromoolefin precursor based on a carbenoid rearrangement, and the resulting Li-acetylide is then trapped in situ with an electrophile to pro