1595288-00-8

Basic information

• Product Name: 2-(cyano(dimethylamino)methyl)phenyl 3-methoxybenzoate
• CAS NO: 1595288-00-8
• Molecular Weight: 310.353
• Mol File: 1595288-00-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(cyano(dimethylamino)methyl)phenyl 3-methoxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(cyano(dimethylamino)methyl)phenyl 3-methoxybenzoate(1595288-00-8)
• EPA Substance Registry System: 2-(cyano(dimethylamino)methyl)phenyl 3-methoxybenzoate(1595288-00-8)

Safety Data

• Hazardous Substances Data: 1595288-00-8(Hazardous Substances Data)

Upstream product

• 23194-66-3 3-methoxybenzoyl cyanide 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 68-12-2 N,N-dimethyl-formamide 

Relevant articles and documents

Three-component synthesis of α-amino-α-aryl carbonitriles from arynes, aroyl cyanides, and N,N-dimethylformamide

A general and efficient synthesis of α-amino-α-aryl carbonitriles through the three-component reaction of arynes, aroyl cyanides, and DMF in a single step is described. DMF was not only used as the solvent, but it also participated in the reaction as a component. Used as the cyanide sources, the aroyl cyanides solved the toxicity and solubility problems associated with the use of HCN or metal cyanides in the Strecker synthesis. This procedure furnished α-amino-α-aryl carbonitriles in moderate to good yields with broad substrate scope. Moreover, this reaction could be performed under mild conditions with high atom economy.