1595288-07-5Relevant academic research and scientific papers
Three-component synthesis of α-amino-α-aryl carbonitriles from arynes, aroyl cyanides, and N,N-dimethylformamide
Zhou, Chao,Wang, Jing,Jin, Jisong,Lu, Ping,Wang, Yanguang
, p. 1832 - 1835 (2014)
A general and efficient synthesis of α-amino-α-aryl carbonitriles through the three-component reaction of arynes, aroyl cyanides, and DMF in a single step is described. DMF was not only used as the solvent, but it also participated in the reaction as a component. Used as the cyanide sources, the aroyl cyanides solved the toxicity and solubility problems associated with the use of HCN or metal cyanides in the Strecker synthesis. This procedure furnished α-amino-α-aryl carbonitriles in moderate to good yields with broad substrate scope. Moreover, this reaction could be performed under mild conditions with high atom economy.
Three-Component Synthesis of α-Amino-α-aryl Carbonitriles from Arynes, Aroyl Cyanides, and N,N-Dimethylformamide
Zhou, Chao,Wang, Jing,Jin, Jisong,Lu, Ping,Wang, Yanguang
supporting information, p. 1832 - 1835 (2015/10/05)
A general and efficient synthesis of α-amino-α-aryl carbonitriles through the three-component reaction of arynes, aroyl cyanides, and DMF in a single step is described. DMF was not only used as the solvent, but it also participated in the reaction as a component. Used as the cyanide sources, the aroyl cyanides solved the toxicity and solubility problems associated with the use of HCN or metal cyanides in the Strecker synthesis. This procedure furnished α-amino-α-aryl carbonitriles in moderate to good yields with broad substrate scope. Moreover, this reaction could be performed under mild conditions with high atom economy. A three-component cascade synthesis of α-amino-α-aryl carbonitriles by using arynes, aroyl cyanides, and DMF in one pot with high atom economy and high bond-formation efficiency is reported. DMF not only works as the solvent but also as a component in the reaction. Given the high solubility of aroyl cyanides in organic solvents, they slowly release cyanide anions over the course of the reaction.
