217813-00-8 Usage
Description
4,5-difluoro-2-(trimethylsilyl)phenyl triflate is a chemical compound that serves as a reagent in organic synthesis. It is characterized by a trifluoromethanesulfonate ester with a phenyl ring substituted by difluoro and trimethylsilyl groups. The triflate group endows this compound with strong electrophilic properties, making it versatile for a range of chemical reactions including nucleophilic substitution, palladium-catalyzed coupling, and fluorination reactions. Its distinctive structural features with difluoro and trimethylsilyl groups render it a valuable asset in the synthesis of intricate organic molecules and pharmaceuticals.
Uses
Used in Organic Synthesis:
4,5-difluoro-2-(trimethylsilyl)phenyl triflate is used as a reagent for its powerful electrophilic nature in various organic synthesis processes. It facilitates reactions such as nucleophilic substitution, where it can be replaced by a nucleophile, and palladium-catalyzed coupling reactions, which are crucial for forming carbon-carbon bonds in complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4,5-difluoro-2-(trimethylsilyl)phenyl triflate is utilized as a key intermediate in the synthesis of complex drug molecules. Its unique combination of difluoro and trimethylsilyl groups allows for the creation of novel pharmaceutical compounds with potential therapeutic applications.
Used in Fluorination Reactions:
4,5-difluoro-2-(trimethylsilyl)phenyl triflate is employed as a fluorinating agent in chemical reactions where the introduction of fluorine atoms is required. The presence of the difluoro groups makes it particularly useful for fluorination processes, which are important for enhancing the properties of organic compounds, including their reactivity, stability, and lipophilicity.
Used in Research and Development:
In research and development settings, 4,5-difluoro-2-(trimethylsilyl)phenyl triflate is used as a tool to explore new chemical reactions and mechanisms. Its unique properties allow chemists to investigate novel pathways and develop innovative synthetic strategies for the creation of new organic compounds and materials.
Check Digit Verification of cas no
The CAS Registry Mumber 217813-00-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,7,8,1 and 3 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 217813-00:
(8*2)+(7*1)+(6*7)+(5*8)+(4*1)+(3*3)+(2*0)+(1*0)=118
118 % 10 = 8
So 217813-00-8 is a valid CAS Registry Number.
217813-00-8Relevant articles and documents
The Versatility of the Aryne-Imine-Aryne Coupling for the -Synthesis of Acridinium Photocatalysts
Hutskalova, Valeriia,Sparr, Christof
supporting information, (2021/07/31)
The increasing use of acridinium photocatalysts as sustainable alternative to precious metal-based counterparts encourages the design and efficient synthesis of distinct catalyst structures. Herein, we report our exploration of the scope of the aryne-imin
A Three-Phase Four-Component Coupling Reaction: Selective Synthesis of o-Chloro Benzoates by KCl, Arynes, CO2, and Chloroalkanes
Jiang, Huanfeng,Zhang, Yu,Xiong, Wenfang,Cen, Jinghe,Wang, Lu,Cheng, Ruixiang,Qi, Chaorong,Wu, Wanqing
supporting information, p. 345 - 349 (2019/01/24)
A transition-metal-free three-phase four-component coupling reaction (3P-4CR) involving KCl, arynes, chloroalkanes and CO2 has been reported for the first time, enabling the incorporation of both chloro and CO2 into an aryne simultaneously. The reactions for the synthesis of different types of o-chloro benzoates can be selectively modulated by the chloroalkane utilized. The corresponding products can be alternatively transformed for postsynthetic functionalizations conveniently.
Tandem nucleophilic addition-cycloaddition of arynes with α-iminoesters: Two concurrent pathways to imidazolidines
Jia, Hao,Guo, Zhenyan,Liu, Honglei,Mao, Biming,Shi, Xueyan,Guo, Hongchao
supporting information, p. 7050 - 7053 (2018/07/05)
The tandem nucleophilic addition-cycloaddition reaction has been developed for the synthesis of functionalized imidazolidine derivatives. A variety of α-iminoesters and aryne precursors were well tolerated under the mild reaction conditions. This asymmetric cycloaddition afforded imidazolidine derivatives with high yields, complete regioselectivities, and excellent diastereo- and enantioselectivities. Aryne-induced ylides working as 1,3-dipoles for asymmetric cycloaddition are the notable feature of the present reaction. In the tandem reaction, the [3+2] cycloaddition of aryne-induced ylides with metallized α-iminoesters and metal-catalyzed [3+2] cycloaddition of azomethine ylide with α-iminoesters are two concurrent pathways to imidazolidines.
