159571-67-2

Upstream product

• 38197-43-2 2-bromo-3-methylanisole 
• 159571-62-7 ((4R,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-(2-methoxy-6-methyl-phenyl)-methanone 
• 159571-64-9 ((4R,5S)-5-Methoxymethoxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-(2-methoxy-6-methyl-phenyl)-methanone 
• 159571-63-8 ((4R,5S)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-(2-methoxy-6-methyl-phenyl)-methanone 
• 81028-12-8 (4S,5R)-4-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane-5-carboxaldehyde 

Downstream Products

• 159571-69-4 (2R,5S)-2-Benzyloxymethyl-5-[(1S,3R)-8-methoxy-1-((4S,5S)-5-methoxymethoxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 159571-68-3 (2R,5S)-2-Benzyloxymethyl-5-[8-methoxy-1-((4S,5S)-5-methoxymethoxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-isoquinolin-3-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthetic Studies on Quinocarcin and Its Related Compounds. 4. Total Synthesis of Enantiomeric Pairs of Quinocarcin and 10-Decarboxyquinocarcin

The title synthesis was accomplished by featuring (i) aldol coupling of the 3-methylanisole 11 with 5-substituted- or 3,5-disubstituted- 2-formylpyrrolidine 4 or 5, (ii) highly diastereoselective reduction of 1,3-disubstituted isoquinolines 14 and 33 to c