159581-73-4Relevant academic research and scientific papers
Amino acids and peptides. XXVIII. Preparation of poly(ethylene glycol) hybrids of Gln-Val-Val-Ala-Gly analogs and their inhibitory effect on papain
Kawasaki, Koichi,Inoue, Sachie,Okada, Yoshio,Iguchi, Shin,Okamoto, Hiroshi
, p. 890 - 892 (1996)
Gln-Val-Val-Ala-Gly is a sequence which is common in cysteine protease inhibitors. Poly(ethylene glycol) hybrids of Gln-Val-Val-Ala-Gly analogs were prepared by the solid phase method by fluorenylmethyloxycarbonyl chemistry. The hybrid formation of Gln-Val-Val-Ala-Gly resulted in improvement of the solubility and also in enhancement of the inhibitory effect of the peptide on papain. In additiohn, the hybrid formation of Gly-Val-Val-Ala-Gly analogs resulted in the enhancement of the inhibitory effect of the peptide analogs.
