Biological and Pharmaceutical Bulletin p. 890 - 892 (1996)
Update date:2022-08-04
Topics:
Kawasaki, Koichi
Inoue, Sachie
Okada, Yoshio
Iguchi, Shin
Okamoto, Hiroshi
Gln-Val-Val-Ala-Gly is a sequence which is common in cysteine protease inhibitors. Poly(ethylene glycol) hybrids of Gln-Val-Val-Ala-Gly analogs were prepared by the solid phase method by fluorenylmethyloxycarbonyl chemistry. The hybrid formation of Gln-Val-Val-Ala-Gly resulted in improvement of the solubility and also in enhancement of the inhibitory effect of the peptide on papain. In additiohn, the hybrid formation of Gly-Val-Val-Ala-Gly analogs resulted in the enhancement of the inhibitory effect of the peptide analogs.
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