Amino acids and peptides. XXVIII. Preparation of poly(ethylene glycol) hybrids of Gln-Val-Val-Ala-Gly analogs and their inhibitory effect on papain

DOI: 10.1248/bpb.19.890

Source and publish data:

Biological and Pharmaceutical Bulletin p. 890 - 892 (1996)

Update date:2022-08-04

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Authors:

Kawasaki, Koichi

Inoue, Sachie

Okada, Yoshio

Iguchi, Shin

Okamoto, Hiroshi

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Article abstract of DOI:10.1248/bpb.19.890

Gln-Val-Val-Ala-Gly is a sequence which is common in cysteine protease inhibitors. Poly(ethylene glycol) hybrids of Gln-Val-Val-Ala-Gly analogs were prepared by the solid phase method by fluorenylmethyloxycarbonyl chemistry. The hybrid formation of Gln-Val-Val-Ala-Gly resulted in improvement of the solubility and also in enhancement of the inhibitory effect of the peptide on papain. In additiohn, the hybrid formation of Gly-Val-Val-Ala-Gly analogs resulted in the enhancement of the inhibitory effect of the peptide analogs.

Full text of DOI:10.1248/bpb.19.890

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