159583-31-0

Basic information

• Product Name: 4-nitro-N-(1,2-dimethyl-4-piperidazyl)benzamide
• Synonyms: 4-nitro-N-(1,2-dimethyl-4-piperidazyl)benzamide
• CAS NO: 159583-31-0
• Molecular Weight: 278.311
• Mol File: 159583-31-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-nitro-N-(1,2-dimethyl-4-piperidazyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-nitro-N-(1,2-dimethyl-4-piperidazyl)benzamide(159583-31-0)
• EPA Substance Registry System: 4-nitro-N-(1,2-dimethyl-4-piperidazyl)benzamide(159583-31-0)

Safety Data

• Hazardous Substances Data: 159583-31-0(Hazardous Substances Data)

Upstream product

• 122-04-3 4-nitro-benzoyl chloride 
• 159583-29-6 1,2-dimethyl-4-aminopiperidazine 
• 35691-30-6 diethyl 3,6-dihydro-1,2-pyridazinedicarboxylate 
• 159583-30-9 1,2-dicarbethoxy-4-aminopiperidazine 

Relevant articles and documents

Synthesis of p-aminobenzamides of aminopiperidazines as potential antiarrhythmic agents

1,2-Dimethyl-4-aminopiperidazine (4), 1-(2-aminoethyl)-2-methylpiperidazine (11), 2-(2-aminoethyl)-3-methyl-2,3-diazabicyclo[2.2.1]heptane (16), and 1,2-dimethyl-3-aminomethylpiperidazine (21) have been synthesized. Amines 4, 11, and 16 were converted to the corresponding p-nitrobenzamides 7, 12, and 17. Catalytic reduction of the latter nitro derivatives gave the corresponding p-aminobenzamides 8, 13, and 18. For comparative studies, the acyclic analog, 4-amino-N-[2-(1,1,2-trimethylhydrazino)ethyl]benzamide (25) was also synthesized. Compounds 8, 13 and 25 which are analogs of procainamide were evaluated in the isolated cardiac Purkinje fiber preparation by measuring their effects on the action potential upstroke velocity.