1596118-89-6

Basic information

• Product Name: 2,2,2-trichloro-1-(1-(2,6-difluorobenzyl)-1H-1,2,3-triazol-4-yl)ethan-1-one
• Synonyms: 2,2,2-trichloro-1-(1-(2,6-difluorobenzyl)-1H-1,2,3-triazol-4-yl)ethan-1-one
• CAS NO: 1596118-89-6
• Molecular Weight: 340.544
• Mol File: 1596118-89-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,2,2-trichloro-1-(1-(2,6-difluorobenzyl)-1H-1,2,3-triazol-4-yl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-trichloro-1-(1-(2,6-difluorobenzyl)-1H-1,2,3-triazol-4-yl)ethan-1-one(1596118-89-6)
• EPA Substance Registry System: 2,2,2-trichloro-1-(1-(2,6-difluorobenzyl)-1H-1,2,3-triazol-4-yl)ethan-1-one(1596118-89-6)

Safety Data

• Hazardous Substances Data: 1596118-89-6(Hazardous Substances Data)

Usage

General Description

The chemical 2,2,2-trichloro-1-(1-(2,6-difluorobenzyl)-1H-1,2,3-triazol-4-yl)ethan-1-one is a synthetic compound with a complex molecular structure. It contains three chlorine atoms, one triazole ring, and a difluorobenzyl group. 2,2,2-trichloro-1-(1-(2,6-difluorobenzyl)-1H-1,2,3-triazol-4-yl)ethan-1-one may be used as a pesticide, pharmaceutical intermediate, or in the production of other chemicals. Its precise properties and potential applications would depend on its specific chemical and physical characteristics, which can be determined through further analysis and research.

Upstream product

• 106308-60-5 2-(azidomethyl)-1,3-difluorobenzene 
• 59938-07-7 (3E)-1,1,1-trichloro-4-ethoxybut-3-en-2-one 
• 697-73-4 2,6-difluorobenzyl chloride 

Downstream Products

• 106308-44-5 rufinamide 
• 1596118-95-4 2-(1-(2,6-difluorobenzyl)-1H-1,2,3-triazolo-4-yl)-1,1,1-chloropent-4-en-2-ol 

Relevant articles and documents

4-Trichloroacetyl-1,2,3-triazoles: A versatile building block for rapid assessment of carbohydrazides and rufinamide derivatives

This work reports the synthesis of a series of (1H-1,2,3-triazol-4-yl)carbohydrazides (2), which were obtained from 4-trichloroacetyl-1H-1,2,3-triazoles (1). Triazoles 1 were synthesized by 1,3-dipolar cycloaddition reaction, starting from 4-alkoxy-1,1,1-trichloroalk-3-en-2-ones and benzyl azides and easily (15 min) converted to 2 by reaction with hydrazine hydrate (73–82% yield). Carbohydrazides 2 proved to be a versatile building block for constructing a series of fluorinated heterocycles analogous to rufinamide, i.e., 1H-1,2,3-triazol-4-yl-1,3,4-oxadiazoles, a pyrrole derivative, and a 2-pyrazoline, through [4+1]–, [1+4]–, and [3+2]–cyclocondensation reactions, respectively. Finally, and according to the Lipinski's rule of five, 2,6-difluorobenzylated 1,2,3-triazoles can be considered as potential candidates for further biological activity assays.