1596355-38-2Relevant articles and documents
Efficient asymmetric Michael reaction of 2-oxindole-3-carboxylate esters with maleimides catalyzed by cinchonidine
Zhou, Jing,Jia, Li-Na,Peng, Lin,Wang, Qi-Lin,Tian, Fang,Xu, Xiao-Ying,Wang, Li-Xin
, p. 3478 - 3484 (2014/05/06)
A highly efficient enantioselective Michael reaction of 2-oxindole-3-carboxylate esters with N-maleimides catalyzed by commercially available cinchonidine was described. The desired adducts, containing a quaternary center at the C3-position and a vicinal tertiary center, were obtained in excellent yields (up to 99%), good enantioselectivities (up to 85% ee), and diastereoselectivities (dr>90:10) in the presence of 0.05-5 mol % catalyst loading.