1596355-55-3

Basic information

• Product Name: ethyl 4,7-dihydro-6-methoxy-4,7-dioxo-2-phenylbenzofuran-3-carboxylate
• CAS NO: 1596355-55-3
• Molecular Weight: 326.306
• Mol File: 1596355-55-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 4,7-dihydro-6-methoxy-4,7-dioxo-2-phenylbenzofuran-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4,7-dihydro-6-methoxy-4,7-dioxo-2-phenylbenzofuran-3-carboxylate(1596355-55-3)
• EPA Substance Registry System: ethyl 4,7-dihydro-6-methoxy-4,7-dioxo-2-phenylbenzofuran-3-carboxylate(1596355-55-3)

Safety Data

• Hazardous Substances Data: 1596355-55-3(Hazardous Substances Data)

Upstream product

• 23030-47-9 2-bromo-6-methoxycyclohexa-2,5-diene-1,4-dione 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 

Relevant articles and documents

Benzofuranquinones as inhibitors of indoleamine 2,3-dioxygenase (IDO). Synthesis and biological evaluation

A series of benzofuranquinones, analogues of the marine metabolite annulin A, has been synthesized and evaluated as inhibitors of human indoleamine 2,3-dioxygenase (IDO). The synthesis was carried out by copper(ii)-mediated reaction of bromobenzoquinones with 1,3-dicarbonyl compounds followed by functional group interconversions. The most potent compounds were 5-methoxy-2-methylbenzofuranquinones containing a CH2OR group at position-3 with IC50 ～ 0.2 mM. The corresponding hydroquinones were inactive. Compounds based on the benzimidazolequinone framework are also active IDO inhibitors. The quinones do not generate significant levels of oxidative stress at concentrations that inhibit IDO. This journal is the Partner Organisations 2014.