159642-10-1Relevant academic research and scientific papers
Acylaminoacetyl derivatives of active methylene compounds. 4. Synthesis of N-protected tetramic acids via the C-acylation reaction of Meldrum's acid with the imidazolides of N-protected glycines
Hamilakis,Kontonassios,Sandris
, p. 825 - 829 (1996)
Meldrum's acid has been found to be effectively acylated using the imidazolides of N-protected glycines, X-NHCH2COOH (X = -COPh, -COMe, -Z, -Boc, -COOMe and -COOEt). The corresponding C-acylation compounds were isolated in high yields and were
Acylaminoacetyl Derivatives of Active Methylene Compounds. 3. C-Acylation Reactions via the Hippuric Acid Azlactone
Hamilakis, Stylianos,Kontonassios, Demetrios,Sandris, Constantine
, p. 1145 - 1150 (2007/10/02)
The C-acylation reactions of the active methylene compounds, methyl cyanoacetate and Meldrum's acid, with hippuric acid, using the DCC activation and the mixed anhydride conditions, are shown to proceed through initial formation of 2-phenyl-5(4H)oxazolone, the hippuric acid azlactone.The conditions of these reactions using the azlactone as the acylating agent were investigated and discussed.
