15965-31-8

Basic information

• Product Name: 4-Chloroimidazole
• Synonyms: 4-Chloro-1H-imidazole;4-Cl-pyrazole;4-Chloroimidazole ,98%;5-Chloro-1H-iMidazole;1H-Imidazole, 5-chloro-;4-CHLOROIMIDAZOLE;5-CHLOROIMIDAZOLE;1H-Imidazole, 4-chloro- (9CI)
• CAS NO: 15965-31-8
• Molecular Formula: C₃H₃ClN₂
• Molecular Weight: 102.52
• Product Categories: Heterocyclic Compounds;Heterocycles
• Mol File: 15965-31-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 118-120°C
• Boiling Point: 295.92 °C at 760 mmHg
• Flash Point: 160.796 °C
• Appearance: Off-white to pale yellow solid
• Density: 1.405
• Vapor Pressure: 0.00261mmHg at 25°C
• Refractive Index: 1.562
• Storage Temp.: Room temperature.
• Solubility: DMSO, Methanol
• PKA: 11.70±0.10(Predicted)
• CAS DataBase Reference: 4-Chloroimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloroimidazole(15965-31-8)
• EPA Substance Registry System: 4-Chloroimidazole(15965-31-8)

Safety Data

• Hazardous Substances Data: 15965-31-8(Hazardous Substances Data)

Usage

Chemical Properties

Off-White to Pale Yellow Solid

Uses

4-Chloro-1H-imidazole (cas# 15965-31-8) is a compound useful in organic synthesis.

InChI:InChI=1/C3H3ClN2/c4-3-1-5-2-6-3/h1-2H,(H,5,6)

Upstream product

• 288-32-4 1H-imidazole 
• 129378-52-5 2-tert-butyldimethylsilyl-N,N-dimethylimidazole-1-sulfonamide 
• 89108-47-4 4-diazo-4H-imidazole 
• 108-90-7 chlorobenzene 

Downstream Products

• 1248592-25-7 methyl {2-[(4-chloro-1H-imidazol-1-yl)methyl]phenyl}acetate 
• 1248592-24-6 methyl {2-[(5-chloro-1H-imidazol-1-yl)methyl]phenyl}acetate 
• 1356009-06-7 1-(2-(allyloxy)-4-nitrophenyl)-4-chloro-1H-imidazole 
• 872-49-1 N-methyl-5-chloroimidazole 
• 1356009-16-9 tert-butyl 3-(2-(4-chloro-1H-imidazol-1-yl)-5-nitrophenoxy)propylcarbamate 
• 1356009-13-6 tert-butyl 2-(2-(2-(4-chloro-1H-imidazol-1-yl)-5-nitrophenoxy)ethoxy)ethylcarbamate 
• 1235492-44-0 4-chloro-1-(2-fluoro-6-methoxy-4-nitrophenyl)-1H-imidazole 
• 1235491-92-5 4-chloro-1-(2-methoxy-4-nitrophenyl)-1H-imidazole 
• 1235492-28-0 4-chloro-1-(2,6-difluoro-4-nitrophenyl)-1H-imidazole 
• 1215015-17-0 C₁₅H₁₆Cl₂N₂OS 
• 1215015-18-1 C₁₅H₁₆Cl₂N₂OS 

Relevant articles and documents

Synthesis and characterization of new N-(4-(4-chloro-1H-imidazol-1-yl)-3- methoxyphenyl)amide/sulfonamide derivatives as possible antimicrobial and antitubercular agents

In this paper we report the SAR studies of a series of N-(4-(4-chloro-1H- imidazol-1-yl)-3-methoxyphenyl)amide and N-(4-(4-chloro-1H-imidazol-1-yl)-3- methoxyphenyl)sulfonamide derivatives 6(a-o) and 7(a-o), were synthesized in good yields and characterized by 1H NMR, 13C NMR and mass spectral analyses. The preparation of the key intermediate highlights an optimized palladium catalyzed (Pd2(dba)3/RuPhos) Buchwald cross-coupling of intermediate 2 and 3. The newly synthesized compounds were evaluated for their in vitro antibacterial activity against Staphylococcus aureus, (Gram-positive), Escherichia coli and Klebsiella pneumoniae (Gram-negative), antifungal activity against Candida albicans, Aspergillus flavus and Rhizopus sp. and antitubercular activity against Mycobacterium tuberculosis H37Rv, Mycobacterium smegmatis, Mycobacterium fortuitum and MDR-TB strains. The synthesized compounds displayed interesting antimicrobial activity. The compounds 7d, 7f, 7h and 7n displayed significant activity against Mycobacterium tuberculosis H37Rv strain.

Novel Bicyclic Pyridinones

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined herein. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Novel imidazobenzazepine derivatives as dual H1/5-HT 2A antagonists for the treatment of sleep disorders

A novel imidazobenzazepine template (5a) with potent dual H 1/5-HT2A antagonist activity was identified. Application of a zwitterionic approach to this poorly selective and poorly developable starting point successfully delivered a class of high quality leads, 3-[4-(3-R1-2-R-5H-imidazo[1,2-b][2]benzazepin-11-yl)-1-piperazinyl]- 2,2-dimethylpropanoic acids (e.g., 9, 19, 20, and 21), characterized by potent and balanced H1/5-HT2A receptor antagonist activities and good developability profiles.