15965-57-8

Basic information

• Product Name: 1H-Benzimidazole,2-chloro-4-methyl-(9CI)
• Synonyms: 1H-Benzimidazole,2-chloro-4-methyl-(9CI);2-CHLORO-4-METHYL-1H-BENZOIMIDAZOLE;2-CHLORO-4-METHYL-1H-BENZIMIDAZOLE;1H-Benzimidazole, 2-chloro-7-methyl-;2-Chloro-4-Methyl-1H-benzo[d]iMidazole;2-Chloro-4-methylbenzimidazole;2-Chloro-7-Methyl-1H-benzo[d]iMidazole
• CAS NO: 15965-57-8
• Molecular Formula: C₈H₇ClN₂
• Molecular Weight: 166.6076
• Product Categories: BENZIMIDAZOLE
• Mol File: 15965-57-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 339.915 °C at 760 mmHg
• Flash Point: 189.91 °C
• Appearance: /
• Density: 1.351
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 10.26±0.30(Predicted)
• CAS DataBase Reference: 1H-Benzimidazole,2-chloro-4-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole,2-chloro-4-methyl-(9CI)(15965-57-8)
• EPA Substance Registry System: 1H-Benzimidazole,2-chloro-4-methyl-(9CI)(15965-57-8)

Safety Data

• Hazardous Substances Data: 15965-57-8(Hazardous Substances Data)

Usage

General Description

1H-Benzimidazole, 2-chloro-4-methyl-(9CI) is a chemical compound with the molecular formula C9H8ClN2. It belongs to the class of benzimidazole compounds, which are heterocyclic organic compounds containing a fusion of benzene and imidazole rings. This particular compound is characterized by the presence of a chlorine atom and a methyl group on the benzimidazole ring. It has a molar mass of 182.62 g/mol and is a white to light yellow solid at room temperature. 1H-Benzimidazole, 2-chloro-4-methyl-(9CI) has potential applications in the pharmaceutical and agrochemical industries, as well as in the synthesis of various organic compounds. Its properties and reactivity make it a versatile building block for the production of other chemical compounds.

Upstream product

• 2687-25-4 3-methyl-1,2-benzenediamine 
• 19190-68-2 4-methyl-1,3-dihydro-2H-benzoimidazol-2-one 
• 19190-68-2 4-methylbenzimidazolone 
• 530-62-1 1,1'-carbonyldiimidazole 

Downstream Products

• 1453097-14-7 3-methyl-1-(4-methyl-1H-benzimidazol-2-yl)-4-(phenylmethyl)-1H-pyrazol-5-ol 

Relevant articles and documents

Nonpolar isosteres of damaged DNA bases: Effective mimicry of mutagenic properties of 8-oxopurines

A substantial fraction of mutations that arise in the cell comes from oxidative damage to DNA bases. Oxidation of purine bases at the 8-position, yielding 8-oxo-G and 8-oxo-A, results in conformational changes (from anti to syn) that cause miscoding durin

QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS

There are disclosed a series of quinuclidines having the Formula (I). which bind to the nicotinic α7 receptor and may be useful for the treatment of disorders of the central nervous system.

Design and synthesis of prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors as anti-prostate cancer drugs

A series of 1-aryl-3,4-substituted-1H-pyrazol-5-ol derivatives was synthesized and evaluated as prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors to obtain a novel anti-prostate cancer drug. After modifying 1-(1H-benzimidazol-2-yl)-3,4-dimethyl-1H-pyrazol-5-ol (1), a hit compound found during random screening using a recombinant PCA-1/ALKBH3, 1-(1H-5- methylbenzimidazol-2-yl)-4-benzyl-3-methyl-1H-pyrazol-5-ol (35, HUHS015), was obtained as a potent PCA-1/ALKBH3 inhibitor both in vitro and in vivo. The bioavailability (BA) of 35 was 7.2% in rats after oral administration. As expected, continuously administering 35 significantly suppressed the growth of DU145 cells, which are human hormone-independent prostate cancer cells, in a mouse xenograft model without untoward effects.