15965-71-6

Usage

Properties

Antiparasitic

Uses

Treatment of tapeworm, roundworm, and fluke infestations in the gastrointestinal tract, liver, and lungs

Mechanism of action

Inhibits uptake of glucose by parasites, causing depletion of energy and eventual death

Administration

Typically in the form of tablets

Safety profile

Few side effects

Application

First-line treatment for parasitic infections in human and veterinary medicine

Upstream product

• 117290-55-8 6-chloro-1,3-dihydro-3-methyl-1-(1-phenylethen-1yl)-2H-benzimidazol-2-one 
• 55239-75-3 N-(4-chlorophenyl)-N-methylcarbamyl chloride 
• 932-96-7 N-methyl(p-chloroaniline) 
• 59681-66-2 4-chloro-1-N-methylbenzene-1,2-diamine 
• 530-62-1 1,1'-carbonyldiimidazole 
• 61911-83-9 7-chloro-1,3-dihydro-4-phenyl-2H-1,5-benzodiazepin-2-one 
• 117290-52-5 7-chloro-2-(2-diethylaminoethylthio)-4-phenyl-3H-1,5-benzodiazepine 
• 95-83-0 4-Chloro-1,2-phenylenediamine 
• 117290-54-7 6-chloro-1,3-dihydro-1-(1-phenylethen-1yl)-2H-benzimidazol-2-one 
• 117290-51-4 7-chloro-1,3-dihydro-4-phenyl-2H-1,5-benzodiazepine-2-thione 

Downstream Products

• 89660-05-9 5-Chloro-1-methyl-3-quinolin-2-yl-1,3-dihydro-benzoimidazol-2-one 
• 79772-43-3 5-Chloro-1-methyl-3-(2-nitro-phenyl)-1,3-dihydro-benzoimidazol-2-one 
• 79759-75-4 3-(4-Amino-phenyl)-5-chloro-1-methyl-1,3-dihydro-benzoimidazol-2-one 
• 79759-74-3 3-(2-Amino-phenyl)-5-chloro-1-methyl-1,3-dihydro-benzoimidazol-2-one 
• 79759-83-4 5-Chloro-3-(4-dimethylamino-phenyl)-1-methyl-1,3-dihydro-benzoimidazol-2-one 
• 89660-08-2 1-methyl-3-(5-tetrazolyl)-5-chlorobenzimidazolin-2-one 
• 37385-92-5 5-chloro-1-methyl-3-phenyl-1,3-dihydro-2H-benzo[d]imidazol-2-one 
• 79759-73-2 5-Chloro-1-methyl-3-(4-nitro-phenyl)-1,3-dihydro-benzoimidazol-2-one 
• 89659-97-2 5-Chloro-1-methyl-3-pyridin-3-yl-1,3-dihydro-benzoimidazol-2-one 
• 89660-07-1 5-Chloro-1-methyl-3-thiazol-2-yl-1,3-dihydro-benzoimidazol-2-one 
• 89660-06-0 5-Chloro-1-methyl-3-thiophen-3-yl-1,3-dihydro-benzoimidazol-2-one 

Relevant academic research and scientific papers

Construction of Benzimidazolone Derivatives via Aryl Iodide Catalyzed Intramolecular Oxidative C-H Amination

The first aryl iodide catalyzed intramolecular C-H amination of phenylurea has been disclosed for high-efficiency synthesis of benzimidazolone derivatives in excellent yields (up to 97%) by an operationally simple one-step organocatalytic oxidative proces

Selective: S -arylation of 2-oxazolidinethiones and selective N -arylation of 2-benzoxazolinones/2-benzimidazolinones

There exist three possible patterns for the reaction of cyclic 2-oxazolidinethione and 2-benzoxazolidinethione with arynes, namely (a) S-arylation, (b) N-arylation, and (c) aryne insertion into the thiocarbonyl group (CS). Our studies demonstrate that S-arylation wins out affording S-aryl dihydrooxazoles. In contrast, for related reactions of cyclic 2-benzoxazolinone and 2-benzimidazolinone with arynes, it is found that N-arylation outcompetes O-arylation and aryne insertion into the CO group to give N-aryl 2-benzoxazolinones and N-aryl 2-benzimidazolinones.