15967-31-4Relevant academic research and scientific papers
Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction
Allen, John G.,Bourbeau, Matthew P.,Wohlhieter, G. Erich,Bartberger, Michael D.,Michelsen, Klaus,Hungate, Randall,Gadwood, Robert C.,Gaston, Rick D.,Evans, Bruce,Mann, Larry W.,Matison, Michael E.,Schneider, Stephen,Huang, Xin,Yu, Dongyin,Andrews, Paul S.,Reichelt, Andreas,Long, Alexander M.,Yakowec, Peter,Yang, Evelyn Y.,Lee, Tani Ann,Oliner, Jonathan D.
experimental part, p. 7044 - 7053 (2010/08/05)
Tumor protein 53 (p53) is a critical regulator of cell cycle and apoptosis that is frequently disabled in human tumors. In many tumor types, p53 is deleted or mutated, but in others p53 is inactivated by overexpression or amplification of its negative reg
