159683-84-8

Upstream product

• 159683-82-6 E-5-t-butyldimethylsilyloxy-3-methylidene-1-pentenyl-phosphonic acid diethyl ester 
• 173192-46-6 diethyl 2-(2-((tert-butyldimethylsilyl)oxy)ethyl)malonate 
• 175543-41-6 Acetic acid 4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxymethyl-butyl ester 
• 159683-81-5 4-{[tert-butyl(dimethyl)silyl]oxy}-2-methylidenebutanal 
• 98-59-9 p-toluenesulfonyl chloride 
• 159683-83-7 E-5-hydroxy-3-methylidene-1-pentenyl-phosphonic acid diethyl ester 
• 396728-63-5 2-[2-(1,1,2,2-Tetramethyl-1-silapropoxy)ethyl]propane-1,3-diol 

Relevant academic research and scientific papers

Synthesis, enzymatic phosphorylation and antiviral activity of acyclic dienyl phosphonate derivatives of guanine

The synthesis, phosphorylation by guanylate kinase, anti HIV-1 and anti-herpesvirus activity of two acyclic dtenyl phosphonate derivatives of guanine are described. (E)-9-(5-phosphono-3-methylene-4-pentenyl)guanine (4) was identified as an excellent substrate of guanylate kinase and a significant inhibitor of HIV-1 replication.

Unsaturated acetylene phosphonate derivatives of purines

Disclosed are novel unsaturated acetylene phosphonate derivatives of certain purines or pyrimidines useful as antiviral agents, methods useful for their preparation and use of these compounds as antiviral agents effective against DNA viruses, retroviruses