Synthesis, enzymatic phosphorylation and antiviral activity of acyclic dienyl phosphonate derivatives of guanine

DOI: 10.1016/0960-894X(95)00585-H

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 179 - 184 (1996)

Update date:2022-08-05

Topics:

Authors:

Nave, Jean-Francois

Casara, Patrick J.

Taylor, Debra L.

Tyms, A. Stanley

Kenny, Michael

Halazy, Serge

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0960-894X(95)00585-H

The synthesis, phosphorylation by guanylate kinase, anti HIV-1 and anti-herpesvirus activity of two acyclic dtenyl phosphonate derivatives of guanine are described. (E)-9-(5-phosphono-3-methylene-4-pentenyl)guanine (4) was identified as an excellent substrate of guanylate kinase and a significant inhibitor of HIV-1 replication.

Full text of DOI:10.1016/0960-894X(95)00585-H

Products guided by the article

Product name:E-5-Tosyloxy-3-methylidene-1-pentenyl-phosphonic acid diethyl ester

Cas No:159683-84-8

R&D Labs maybe for 159683-84-8

Jinan Hongfangde Pharmatech Co.,Ltd

Contact:86-531-88870908

Address:F Bldg. West Unit North Area of Univ. Tech. Garden Xinyu Rd. Jinan New & High Tech Industry Development Zone Shandong, China
Wuxi Zuping Food Science And Technology Co.,LTD.

Contact:+86-510-87210822

Address:Guanlin town
Chengdu ZY Biochemical Technology Co., LTD

Contact:0086-28-88680086

Address:170 Qingpu Road, Shouan Town, Pujiang County
Changzhou Foreign Trade Corp

Contact:+86-519-86623222

Address:29F/D, 99 Yanling West Road, Changzhou, Jiangsu, China
Chengdu Boon Stream Chemical Industry Co.,Ltd.

Contact:+86-28-83156758

Address:No.859,Dongzikou Road,Jinniu District,Chengdu,Sichuan,P.R.China

Relevant to this article

Rhodium catalyzed direct arylation of α-diazoimines

Doi:10.1021/ol500874p
(2014)
Reactivity of [K₃(phen)₈][Cu(NPh₂) ₂]₃ - A possible intermediate in the copper(i)-catalyzed N-arylation of N-phenylaniline

Doi:10.1039/c4dt00051j
(2014)
Doi:10.1039/jr9620001490
(1962)
Three-component Pd/Cu-catalyzed cascade reactions of cyclic iodoniums, alkynes, and boronic acids: An approach to methylidenefluorenes

Doi:10.1021/ol5006714
(2014)
Studies on aryl H-phosphonates. I. An efficient method for the preparation of deoxyribo- and ribonucleoside 3'-H-phosphonate monoesters by transesterification of diphenyl H-phosphonate

Doi:10.1016/S0040-4039(00)76906-1
(1994)
Core modification of substituted piperidines as Novel inhibitors of HDM2-p53 protein-protein interaction

Doi:10.1016/j.bmcl.2014.02.055
(2014)

Article Doi