Synthesis, enzymatic phosphorylation and antiviral activity of acyclic dienyl phosphonate derivatives of guanine

DOI: 10.1016/0960-894X(95)00585-H

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 179 - 184 (1996)

Update date:2022-08-05

Topics:

Authors:

Nave, Jean-Francois

Casara, Patrick J.

Taylor, Debra L.

Tyms, A. Stanley

Kenny, Michael

Halazy, Serge

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Article abstract of DOI:10.1016/0960-894X(95)00585-H

The synthesis, phosphorylation by guanylate kinase, anti HIV-1 and anti-herpesvirus activity of two acyclic dtenyl phosphonate derivatives of guanine are described. (E)-9-(5-phosphono-3-methylene-4-pentenyl)guanine (4) was identified as an excellent substrate of guanylate kinase and a significant inhibitor of HIV-1 replication.

Full text of DOI:10.1016/0960-894X(95)00585-H

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