Bioorganic and Medicinal Chemistry Letters p. 179 - 184 (1996)
Update date:2022-08-05
Topics:
Nave, Jean-Francois
Casara, Patrick J.
Taylor, Debra L.
Tyms, A. Stanley
Kenny, Michael
Halazy, Serge
The synthesis, phosphorylation by guanylate kinase, anti HIV-1 and anti-herpesvirus activity of two acyclic dtenyl phosphonate derivatives of guanine are described. (E)-9-(5-phosphono-3-methylene-4-pentenyl)guanine (4) was identified as an excellent substrate of guanylate kinase and a significant inhibitor of HIV-1 replication.
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