159685-68-4

Upstream product

• 829-85-6 diphenylphosphane 
• 159685-67-3 2-<(aR^*,3'R,5'R)-3',5'-bis<(tert-butyldimethylsilyl)oxy>-4'-<(trimethylsilyl)oxy>cyclohexylidene>ethanol 
• 159685-67-3 2-<(aS^*,3'R,5'R)-3',5'-bis<(tert-butyldimethylsilyl)oxy>-4'-<(trimethylsilyl)oxy>cyclohexylidene>ethanol 

Downstream Products

• 160399-86-0 (1R,3aS,7aR)-4-[2-{(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-4-[3-(tert-butyl-dimethyl-silanyloxy)-propoxy]-cyclohexylidene}-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-7a-methyl-octahydro-indene 
• 160399-84-8 1α-<(tert-butyldimethylsilyl)oxy>-2β-hydroxy-25-<(triethylsilyl)oxy>-19-norvitamin D3 tert-butyldimethylsilyl ether 
• 160313-17-7 (1R,3aS,7aR)-4-[2-[(3R,5R)-4-Benzyloxy-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-cyclohexylidene]-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-7a-methyl-octahydro-indene 
• 160399-86-0 (1R,3aS,7aR)-4-[2-{(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-4-[3-(tert-butyl-dimethyl-silanyloxy)-propoxy]-cyclohexylidene}-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-7a-methyl-octahydro-indene 
• 160399-84-8 1α-<(tert-butyldimethylsilyl)oxy>-2α-hydroxy-25-<(triethylsilyl)oxy>-19-norvitamin D3 tert-butyldimethylsilyl ether 

Relevant academic research and scientific papers

Synthesis of a-ring synthon of 19-nor-1alpha,25-dihydroxyvitamin D3 from (D)-glucose

The present invention provides a method for the synthesis of an A-ring synthon phosphine oxide used in the preparation of 19-nor vitamin D compounds, and to novel synthetic intermediates formed during the synthesis. The new method prepares the phosphine oxide from (D)-glucose.

Synthesis and biological activity of 2-hydroxy and 2-alkoxy analogs of 1α,25-dihydroxy-19-norvitamin D3

1α,2α,25-Trihydroxy-19-norvitamin D3, 1α,2β,25-trihydroxy-19- norvitamin D3, and their alkoxy analogs were efficiently prepared in a convergent synthesis, starting with (-)-quinic acid and a Windaus-Grundmann type ketone. Configurati