159692-72-5Relevant academic research and scientific papers
Syntheses of oxidized metabolites implicated as active forms of the highly potent carcinogenic hydrocarbon dibenzo[def,p]chrysene
Zhang,Harvey
, p. 625 - 636 (2007/10/03)
Polycyclic aromatic hydrocarbons (PAHs) are an important class of environmental carcinogens, and dibenzo[def,p]chrysene is the most potent carcinogenic PAH currently known. Syntheses of various oxidized metabolites of dibenzo[def,p]chrysene implicated as the biologically active forms that interact directly or indirectly with DNA to induce mutations that lead to tumor induction are reported. These include the 8,9- and 11,12-dihydrodiols (2 and 3), the 8,9,11,12-bis-dihydrodiol (5), and the fjord region anti-diol epoxide derivative of 3 (4).
