878197-67-2Relevant articles and documents
Imidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV-1
Gudmundsson, Kristjan S.,Boggs, Sharon D.,Catalano, John G.,Svolto, Angilique,Spaltenstein, Andrew,Thomson, Michael,Wheelan, Pat,Jenkinson, Stephen
scheme or table, p. 6399 - 6403 (2010/05/02)
Synthesis of several novel imidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV are described. Synthetic approaches allowing for variation of the substitution pattern are outlined and resulting changes in antivir
Kilogram-scale synthesis of the CXCR4 antagonist GSK812397
Boggs, Sharon,Elitzin, Vassil I.,Gudmundsson, Kristjan,Martin, Michael T.,Sharp, Matthew J.
scheme or table, p. 781 - 785 (2010/04/22)
An improved, scalable synthesis of the CXCR4 antagonist GSK812397 is described. This new route was recently scaled up in 50 L fixed equipment to afford 1.2 kg of drug substance in five steps with an overall yield of 20% and >99% chemical and enantiomeric
CHEMICAL COMPOUNDS
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Page/Page column 35-36, (2008/06/13)
The present invention provides compounds that demonstrate protective effects on target cells from HIV infection in a manner as to bind to chemokine receptor, and which affect the binding of the natural ligand or chemokine to a receptor such as CXCR4 of a
CHEMICAL COMPOUNDS
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Page/Page column 44-45; 59-60, (2010/11/28)
The present invention provides compounds that demonstrate protective effects on target cells from HIV infection in a manner as to bind to chemokine receptor, and which affect the binding of the natural ligand or chemokine to a receptor such as CXCR4 of a
CHEMICAL COMPOUNDS
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Page/Page column 40-41, (2008/06/13)
There is provided novel compounds that demonstrate protective effects on target cells from HIV infection in a manner as to bind specifically to the chemokine receptor, and which affect the binding of the natural ligand or chemokine to a receptor such as C
CHEMCIAL COMPOUNDS
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Page/Page column 60-61, (2010/10/20)
The present invention provides novel compounds that demonstrate protective effects on target cells from HIV infection in a manner as to bind specifically to the chemokine receptor, and which affect the binding of the natural ligand or chemokine to a receptor such as CXCR4 and/or CCR5 of a target cell.
CHEMICAL COMPOUNDS
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Page/Page column 65, (2010/11/08)
The present invention provides novel compounds that demonstrate protective effects on target cells from HIV infection in a manner as to bind specifically to the chemokine receptor, and which affect the binding of the natural ligand or chemokine to a recep
CHEMICAL COMPOUNDS
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Page/Page column 44-45, (2008/06/13)
The present invention provides compounds of Formula (I) comprising: including salts, solvates, and physiologically functional derivatives thereof, pharmaceutical formulations containing them, processes for their preparation, and methods of treatment using them.