1597-36-0

Basic information

• Product Name: 4(1H)-Pyrimidinone, 2-amino-6-(fluoromethyl)- (9CI)
• Synonyms: 4(1H)-Pyrimidinone, 2-amino-6-(fluoromethyl)- (9CI);2-amino-6-(fluoromethyl)-1H-pyrimidin-4-one;2-azanyl-6-(fluoromethyl)-1H-pyrimidin-4-one
• CAS NO: 1597-36-0
• Molecular Formula: C5H6FN3O
• Molecular Weight: 143.1190432
• Product Categories: PYRIMIDINE
• Mol File: 1597-36-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 250-260 °C (decomp)(Solv: acetic acid (64-19-7))
• Boiling Point: 266.9°Cat760mmHg
• Flash Point: 115.2°C
• Appearance: /
• Density: 1.57g/cm³
• Vapor Pressure: 0.0084mmHg at 25°C
• Refractive Index: 1.617
• PKA: 8.71±0.50(Predicted)
• CAS DataBase Reference: 4(1H)-Pyrimidinone, 2-amino-6-(fluoromethyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Pyrimidinone, 2-amino-6-(fluoromethyl)- (9CI)(1597-36-0)
• EPA Substance Registry System: 4(1H)-Pyrimidinone, 2-amino-6-(fluoromethyl)- (9CI)(1597-36-0)

Safety Data

• Hazardous Substances Data: 1597-36-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C5H6FN3O/c6-2-3-1-4(10)9-5(7)8-3/h1H,2H2,(H3,7,8,9,10)

Upstream product

• 50-01-1 guanidine hydrochloride 
• 92311-40-5 2-amino-4-fluoro-6-fluoromethylpyrimidine 

Relevant articles and documents

Process for 4,6-di-substituted 2-aminopyrimidines

New compounds useful as intermediates for biologically-active compounds have the formula I STR1 wherein Y is a group having the formula --CH2 X in which X is F, Cl, or Br, or Y is a group having the formula STR2 in which R2 is F, Cl or Br and R3 is H, F, Cl, Br or a group having the formula --CR4 R5 R6, in which R4, R5 and R6, independently, are F, Cl or Br; A is H, OH, SH, F, Cl, Br or a group --OR7 or --SR7 in which R7 is C1 -C4 straight- or branched chain alkyl, C2-4 straight- or branched chain alkyl substituted with 1 to 3 F, Cl or Br atoms, or A is a group --NR8 R9 in which R8 and R9, independently, are H, C1 -C4 straight- or branched chain alkyl or C3 -C4 alkenyl, or R8 and R9 together may form a C3 -C7 polymethylene chain, which is optionally interrupted by an oxygen atom; as well as salts of compounds of formula I with acids; provided that: when Y is CH2 F, then A is as hereinbefore defined other than OH, Cl or OCH3.