159724-49-9

Upstream product

• 10202-87-6 1-(3-amino-2-nitrophenyl)ethanone 
• 194784-10-6 acetic acid-(2-acetyl-6-nitro-anilide) 
• 5234-26-4 N-(2-acetylphenyl)acetamide 
• 7463-31-2 3-Acetamidoacetophenone 
• 99-03-6 1-(3-aminophenyl)ethanone 
• 92642-18-7 N-(3-acetyl-2-nitrophenyl)acetamide 
• 20864-49-7 2-amino-3-nitroacetophenone 

Downstream Products

• 201411-97-4 4-acetyl-2-(2-phenylethyl)benzimidazole 
• 201412-00-2 4-acetyl-2-benzylbenzimidazole 
• 1438559-38-6 phenyl(quinoxalin-5-yl)methanone 
• 89334-34-9 1-(quinoxalin-5-yl)ethanone 

Relevant academic research and scientific papers

Direct exchange of a ketone methyl or aryl group to another aryl group through ciC bond activation assisted by rhodium chelation

Swapped: Commercially available quinolinone derivatives (1 or 2, see scheme) were reacted with arylboronic acids in the presence of a RhI complex to give aryl(quinolin-8-yl)methanone products 3 in medium to good yields. A mechanism that involves the in situ oxidation of RhI to RhIII by O2 in the presence of CuI was proposed. Copyright

DIHYDROOROTATE DEHYDROGENASE INHIBITORS

The invention relates to compounds of formula (I) wherein R1, R2, X1, X2, Y, Ra, Rb, Q have the meanings given in claim 1. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis and also in the treatment of cancer disorders.

Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation

Indazole compounds that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating, e.g., kinases-dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.