5234-26-4

Basic information

• Product Name: N-(2-ACETYL-PHENYL)-ACETAMIDE
• Synonyms: N-(2-ACETYL-PHENYL)-ACETAMIDE;2'-(Acetylamino)acetophenone;o-Acetylaminoacetophenone;2'-Acetamidoacetophenone;N-(2-ethanoylphenyl)ethanamide
• CAS NO: 5234-26-4
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.19984
• Mol File: 5234-26-4.mol
• Article Data: 59

Chemical Properties

• Melting Point: 77 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 367.4 °C at 760 mmHg
• Flash Point: 165.1 °C
• Appearance: /
• Density: 1.15 g/cm³
• Vapor Pressure: 1.37E-05mmHg at 25°C
• Refractive Index: 1.57
• PKA: 14.56±0.70(Predicted)
• CAS DataBase Reference: N-(2-ACETYL-PHENYL)-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-ACETYL-PHENYL)-ACETAMIDE(5234-26-4)
• EPA Substance Registry System: N-(2-ACETYL-PHENYL)-ACETAMIDE(5234-26-4)

Safety Data

• Hazardous Substances Data: 5234-26-4(Hazardous Substances Data)

Usage

General Description

N-(2-Acetyl-phenyl)-acetamide, also known as N-acetylphenyl acetamide, is a chemical compound with the molecular formula C10H11NO2. It is a derivative of acetaminophen and is commonly used as an analgesic and antipyretic agent. N-(2-Acetyl-phenyl)-acetamide is often used in over-the-counter pain relief medications and is known for its mild to moderate pain-relieving effects. It works by inhibiting the production of prostaglandins, which are responsible for causing pain and fever. N-(2-ACETYL-PHENYL)-ACETAMIDE is considered safe when used in appropriate doses and is widely used as an active ingredient in various pharmaceutical products.

InChI:InChI=1/C10H11NO2/c1-7(12)9-5-3-4-6-10(9)11-8(2)13/h3-6H,1-2H3,(H,11,13)

Upstream product

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• 111-34-2 -butyl vinyl ether 
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• 118-92-3 anthranilic acid 
• 1196979-22-2 N-(2-ethynylphenyl)-N-[(1E)-3-methoxyprop-1-enyl]acetamide 
• 111409-79-1 1-bromo-2-(triisopropylsilyl)acetylene 
• 1173504-88-5 N-(2-((triisopropylsilyl)ethynyl)phenyl)acetamide 
• 98-86-2 acetophenone 
• 75-05-8 acetonitrile 
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Downstream Products

• 131423-38-6 [E]-3-phenyl-1-(2-acetamidophenyl)prop-2-en-1-one 
• 60025-28-7 2-(2-N-Acetylamino-benzoyl)-1-indanon 
• 41019-20-9 N-(2-acetyl-4-nitro-phenyl)-acetamide 
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• 1837-71-4 2,4-dimethylquinazoline 3-oxide 
• 58585-01-6 1-(2-amino-phenyl)-2-bromo-ethanone 
• 102908-42-9 3-(2-aminophenyl)-3-oxopropanenitrile 
• 32580-41-9 1-(2-amino-5-nitro-phenyl)ethanone 
• 1028305-45-4 N-(2-Acetyl-4-amino-phenyl)-3-chloro-benzamide 
• 1026981-84-9 N-(2-Acetyl-4-amino-phenyl)-3-methoxy-benzamide 
• 1027220-97-8 N-(2-Acetyl-4-nitro-phenyl)-3-chloro-benzamide 
• 1027302-60-8 N-(2-Acetyl-4-amino-phenyl)-3-trifluoromethyl-benzamide 
• 1026916-62-0 N-(2-Acetyl-4-nitro-phenyl)-3-trifluoromethyl-benzamide 

Relevant articles and documents

An Iron(III) Superoxide Corrole from Iron(II) and Dioxygen

A new structurally characterized ferrous corrole [FeII(ttppc)]? (1) binds one equivalent of dioxygen to form [FeIII(O2?.)(ttppc)]? (2). This complex exhibits a 16/18O2-isotope sensitive ν(O-O) stretch at 1128 cm?1 concomitantly with a single ν(Fe-O2) at 555 cm?1, indicating it is an η1-superoxo (“end-on”) iron(III) complex. Complex 2 is the first well characterized Fe-O2 corrole, and mediates the following biologically relevant oxidation reactions: dioxygenation of an indole derivative, and H-atom abstraction from an activated O?H bond.

Auto-tandem PET and EnT photocatalysis by crude chlorophyll under visible light towards the oxidative functionalization of indoles

Chlorophyll is the most abundant photocatalytic pigment that enables plants to absorb solar energy and convert it to energy storage molecules. Herein, we report a tandem photocatalytic approach utilizing the natural pigment chlorophyll in crude form to achieve photoinduced electron transfer (PET) and energy transfer (EnT) towards the oxidative functionalization of indoles. Redox potentials, ESR, fluorescence quenching and UV experiments have evidenced the dual catalytic activity of chlorophyll. The highlight of the study is the auto-tandem photocatalytic role of chlorophyll to enable the green oxidation of indoles using molecular oxygen as the oxidant, water as the reaction medium, and photochemical energy from the visible region of the spectrum.

Visible-Light-Mediated Dearomatisation of Indoles and Pyrroles to Pharmaceuticals and Pesticides

Dearomatisation of indole derivatives to the corresponding isatin derivatives has been achieved with the aid of visible light and oxygen. It should be noted that isatin derivatives are highly important for the synthesis of pharmaceuticals and bioactive compounds. Notably, this chemistry works excellently with N-protected and protection-free indoles. Additionally, this methodology can also be applied to dearomatise pyrrole derivatives to generate cyclic imides in a single step. Later this methodology was applied for the synthesis of four pharmaceuticals and a pesticide called dianthalexin B. Detailed mechanistic studies revealed the actual role of oxygen and photocatalyst.